The Expression Of CLC-3 In Acute Cardiac Allograft Rejection In Rat

Heart transplantation has been put in practice extensively in clinic surgery in recent years, getting good clinic curative effect. The amount of heart transplantation increases with the speed of about 4000 instances a year. A group of patients with high living standard and long life have appealed. However, acute or chronic cardiac allograft rejection and the negative effects of using immuno-suppressant medications and anti - rejection medications are still the key factors influencing the function of transplant, living period and living standard of the acceptances. Apoptosis , also called programmed cell death (PCD), which is very important to maintain the normal structure and rational reconstruction of hearts, is an active mode of cell death. Many researches on animal models and endocar-dial biopsy on human cardiac muscles proved that the apoptosis of cardiac muscles widely exists in the urgent immunological rejection effect, transplant coronary artery diseace and the unliving transplants caused by heart transplantation. Bcl - 2 and Bax are a pair of molecules most closely related with cell death. Masashi and Murray H, etc. discovered that high expression Bcl -2 can alleviate ischemical repeifusion injury,acult cardiac allograft rejection and transplant coronary artery diseace and decrease Apoptosis of cardiac muscles, through a transgenic research.The iron transportation plays a very important role in ischemic reperfusion injury, the regulation of cell volume and apoptosis. Different cellular transgenic researches showed Bcl - 2 may participate in the regulation of the function of many iron channels that high expressed Bcl - 2 may enhance the ability of the membrane transportation of iron calcium, depress the voltage - gated potassium...