Research Of Absorptive Principle And Sustained-release Preparation About Panax Notoginseng Saponions

Modern Traditional Chinese Medicine (TCM) preparations are embodi -ments of the modernization of TCM. However, in order to modernize TCM preparations, it is more important to modernize the theoretical basis of dosage forms selected and the method for screening prescriptions, optimizing technics and evaluating quality than only to modernize pharmaceuical technique. Biopharmaceutics and Pharmacokinetics are subjects focusing on studying the regularities of drug's absorption, distribution, metabolism and elimination in vivo, and further elucidating the relationships between preparational factors, biological factors and drug effects. Thus, the purpose of this study is to provide novel ideas and approaches for selecting dosage forms, screening prescriptions, optimizing technics and evaluating quality by utilizing the latest measures and models of biopharmaceutics and pharmacokinetics.Danqi, a complex TCM preparation, is widely used to treat coronary disease. In the present study, panax notoginseng saponions (PNS) was used as model drug, mutiple-model including rat in situ perfusion preparation and kinetic research in vivo was employed to investigate systemically absorptive mechanism and the best absorptive segment of the main componentss of PNS, and effect of some common absorptive promoters on the absorptive mechanism and kinetics of PNS. The results clearly indicated that the main componentss of PNS have high solubility and low permeability. The absorption mechanisms of PNS across the intestinal epithelium are rather complex and involve active transport and passive diffusion; paracellular route transportation may also play a part in this process. Borneol and cabomer can enhance absorption of PNS, which may be related to the increase of...