The Studies About The Effects Of Oral Carcinoma-associated Fibroblasts On The Biological Characteristics Of A Lingual Carcinoma Cell Line And Its Mechanisims

[Background] Recent studies have shown tumor-host interface microenvironment, which consists of aberrant epithelial cells and surrounding host mesenchymal components, deeply influences the occurrence and development of tumors. Carcinoma-associated fibroblasts(CAFs) are the primary host mesenchymal cells in this microecological system. They not only have distinct morphological and biological characteristics, but also promote the initiation and progression of many tumors, such as prostatic carcinoma. The etiopathogenesis of oral squamous cell carcinoma(OSCC) has not been elucidated completely. In the past, most research only focused on aberrant epithelial cells or mesenchyme, and ignored the interaction between epithelial cells and adjacent host mesenchyme. Our team has applied the theory of tumor-host interface microenvironment to the...