The Role Of Maspin In Angiogenesis And The Regulation Mechanism Of Maspin Expression In Ovarian Carcinoma

Backgroud: Ovarian cancer is the most lethal gynecological malignancy. Being lack of effective early diagnostic strategies, most ovarian cancers are detected at advanced stages. Although most ovarian cancer is sensitive to chemotherapy, the toxicity, side effects and resistance of chemotherapy bring difficulties to the treatment of ovarian cancer in clinical practice. Recent researches indicate that angiogenesis plays a major role in carcinogenesis and metastasis. Anti-angiogenesis agent is regarded as a new treatment strategy for ovarian cancers due to the abundant blood vessels and rapid growth. Maspin is a new member of the serpin (serine protease inhibitors) superfamily. Numerous researches of maspin revealed that it can act as a tumor suppressor and can block tumor growth, invasion and metastasis in breast and prostate tumors obviously. Moreover, recent studies have proved it to be an effective anti-angiogenesis factor.Objective: The study was performed to detect the expression of maspin, VEGF, HPA protein in ovarian carcinoma and to evaluate the effect of over-expressive maspin on cell proliferation ability, expression of VEGF and heparanase. In addition, the effect of p63 protein on the activation of maspin...