Expression Of P27～(KIP1) Gene In Hepatocellular Carcinoma And Effect Of P27～(KIP1) On Cell Cycle And Apoptosis Regulation In The Hepatocellular Carcinoma Cells

Cell cycle and apoptosis regulation play an important role in tumor pathogenesis and therapy. To explore the exact mechanisms of cell cycle and apoptosis regulation will provide some new thought for overcoming tumors. Hepatocellular carcinoma (HCC) is one of the most common neoplasm in China, its morbidity ranks the third and the death rate ranks the second among all kinds of neoplasm. The post-operation reoccurrence rate of HCC is very high, its susceptibilities to chemotherapy and radiotherapy are very low and the effects of the treatment with immunotherapy and intervention are not perfect. Along with the progress of the molecular biology research, the gene therapy of neoplasm is becoming an optional treatment.p27^KIP1, a member of the cip/kip family of the CDK (cyclin-dependent kinase) inhibitors, is identified as a negative growth regulator present in cells. p27^KIP1 binds to a wide variety of cyclin/CDK complexes including CDK2 and CDK4, inhibits kinase activity, and plays a role in cell-cycle arrest at the G₁ phase. Recent studies have implicated p27^KIP1 as a promoter of apoptosis.