Paste Paste On Human Umbilical In Preparation On Transdermal Drug Delivery Points For The Suitability Study

[Objective] In order to clarify the scientific and the theoretical basis of the umbilical point to transdermal drug delivery, to establish the common technology and quality evaluation system of umbilical point to transdermal drug delivery and to provide the scientific basis for the creation morden prepration of umbilical point to transdermal drug delivery. [Method] We read documentation about umbilical point to transdermal drug delivery and research from the meridian, anatomy, physiology, clinical application, pharmaceutical pharmacy and drug percutaneous absorption theory. Respectively,white peony and the ethanol extract of corydalis herbal medicine as raw materials,use of the modern new excipient such as unsaturated fatty acid glyceride,cocoa butter,polyethylene glycol, glycerin-gelatin-water polo sharm as the substrate to fat-soluble Azone,water-soluble Azone and dimethyl sulfoxide were prepared to promote the transdermal absorbent paste paste, Franz diffusion cell simulation of the human body through the percutaneous absorption process, carried out process preparation study of different delivery systems; We take irritation test and allergic test to the guinea pig skin and make pharmacodynamic studies through the writhing and hot plate method. [Result] Yan Shao paste paste which uses glycerin- gelatin-water as the substrate and 3% fat-soluble Azone as penetration enhancer has the best effect of percutaneous absorption;Yan Shao paste paste has no allergic effect to the guinea pig intact skin and damaged skin;The effect of relieving pain of Yan Shao paste paste is recognized. [Conclusion] In the studies of the umbilical point to transdermal drug delivery the substrate and penetration should take filtration test to determine the suitablity relationship between them and the medicine;The use of extracorporal penetration experiment is a suitable pharmacokinetics method to filter the substrate and penetration enhancer;The umbilical point to transdermal drug delivery of Yan Shao paste paste has security,effectiveness,stability and controllability.