To Study The Suitability Of Navel Transdermal Deliver System Which Used Cocoa Butter As Matrix

With the continuous progress of science and technology, navel transdermal drug delivery system in the hole because of its unique advantages are the people more and more attention, it has the general form the transdermal drug delivery can be avoided with the "first pass effect" in reducing bad reaction, enhance the therapeutic index drugs, improving medication compliance and other advantages, but also as a unique umbilical structures in the cave has a transmittance of higher efficacy and better advantage, so in the pharmacy field has been rapid development.In this experiment, cocoa butter as a substrate, respectively, white peony and the ethanol extract of Corydalis herbal medicine as raw materials to fat-soluble Azone, water-soluble Azone and dimethyl sulfoxide were prepared to promote the transdermal absorbent paste paste, Franz diffusion cell simulation of the human body through the percutaneous absorption process, carried out in vitro penetration test, to clarify the drug, matrix, and promote the relationship between transdermal absorbent and suitability; through the mouse skin test and allergic skin irritation test posted paste made of the safety evaluation, experimental results show that the preparation is safe for clinical application to provide security protection; through the writhing and hot plate method for pharmacodynamic studies, that extend Shao paste paste on mouse have analgesic effects, indicating percutaneous absorption preparation has good effect; by comparing human umbilical and other parts of the skin, Transdermal verify the umbilical in the hole compared to other parts of the superiority of transdermal drug delivery.Through these experiments, he clarified the cocoa paste to paste the matrix of umbilical points transdermal drug delivery system suitability for transdermal drug delivery umbilical points posted in the preparation of paste screening matrix, accessories, and promote transdermal absorbent provides experimental methods and techniques, forming a suitable umbilical Point to transdermal drug delivery system for preparation of key technologies and accessories system.