To Study The Suitability Of Navel Transderal Deliver Agents Which Used Water-Glycerin-Gelatin As Substrate

Umbilical administration for the Chinese medical disease outside the main methods of treatment, external treatment is the treasure house of precious Chinese medicine left the motherlandProduction, its rich in content, methods range. However, for the treatment of some syndromes, 80% of all points in the navel of transdermal drug delivery. Navel as part of a special administration in vitro, in the ages has been the physicians of all ages. The National Eleventh Five Year Plan project is supporting the project topic "Modern agent administered in umbilical suitability of the cave," a part of finishing the first review a number of ancient and modern literature, the first inspection of this project, summarized, reviewed information on more than 600 articles, from pharmaceutics, anatomy, meridian, physiology, clinical applications, drug percutaneous absorption theory, and many other directions, to clarify the umbilical in the hole to be scientific and theoretical basis; by pharmacokinetics, drug Science, pharmacodynamics and other experiments, from the preparations, transdermal effect, safety, efficacy and so on, to clarify the umbilical Point to the appropriateness of transdermal drug delivery and key technology; to create umbilical Point to provide a transdermal drug delivery science and technology.In this experiment, Glycerin-Gelatin as a substrate to ethanol extract of peony fumarate as the raw material medicine, on the navel point transdermal drug delivery in preparation for the study. Glue as a delivery system for Gan Youming to water-soluble Azone, fat-soluble Azone and DMSO for the promotion through absorbent, with over Franz diffusion cell in vitro penetration test, in order to paeoniflorin, Tetrahydropalmatine for the detection of indicators that summarize the drug through the law, the system described the drug, matrix, and promote the relationship between transdermal absorbent. Clarified gelatin glycerin water points in the navel of the appropriateness of transdermal drug delivery. Umbilical points established in the plastic matrix transdermal delivery Ganyou Ming quality evaluation system.In human umbilical point through transdermal drug delivery and other parts of the skin dose comparison study, results of umbilical Point to transdermal drug delivery through the volume is 2 times higher than other parts, confirmed the umbilical Point to the advantages of transdermal drug delivery.Toxicology and efficacy studies, experimental by irritating the skin, allergic and analgesic pharmacodynamics experiments proved Ganyou Ming glue in the hole for the navel matrix transdermal drug delivery posted paste the safety and effectiveness.