Five Internal Organs, Yin And Yang, The Overall On Arthralgia Mechanism Clinical And Experimental Research - Joint Arthromyodynia With Lung Paralysis Occurs

The core of theoretical system of TCM is "visceral manifestation theory".It think that the five visceral is an organic whole, their physical interaction with each other in the pathological mass change although they have their own physiological functions. Rheumatoid arthritis belongs to the scope of "arthralgia" in TCM. The disease is easy to mass change, and very difficult to cure. Our departure from the concept of the five internal organs as a whole, To explore joint Arthralgia mass change related to lung paralysis. and to explore the kidney in the mechanism of joint Arthralgia related lung damage.Which will offord mechanism of molecular biology basis for joint Arthralgia lung damage, and pave the way to improve clinical outcomes.1 PurposeSorting through the literature on the holism thinking of the five organs of yin and yang, And rheumatoid arthritis with interstitial lung disease, clinical observations, experimental research, Discuss rheumatoid arthritis occur related mechanism of lung damage and kidney disease, Significance in guiding clinical treatment.2 Methods2.1 Theoretical Study Use philology, logic analysis ways, Discuss analysis of the connotation of TCM "holism" of the five internal organs, Explore joint Arthralgia and pulmonary paralysis occurred, and to explore the kidney in joint Arthralgia related lung damage.2.2 Experimental study2.2.1 We selected 16 female SD rats Randomly, and then causing arthralgia model with Inject of CIA.Observed the pathological changes of the of arthralgia model of lung tissue, calculated the lung coefficient, analysised content of IL-1, IL-6, TNF-alpha and TGF-P of lung tissue.2.2.2 We selected 64 SD rats randomly, male and female half. Made the arthralgia model, kidney arthralgia model, pseudo-operation group model. Calculated the index of thymus. Analysised content of IL-1, IL-6, TNF-alpha and TGF-βof lung tissue.3 Result3.1 The effect of arthralgia pass to lung3.1.1 Arthralgia model group rats had lung pathological changes. And compared with the physiological group, lung coefficient is higher than the physical group, statistically significant(P<0.05). 3.1.2 Compared with the physiological group, the content of IL-1, IL-6, TNF-alpha, TGF-beta significantly increased in lung, statistically significant(P<0.05).3.2 The role of renal in pathogenesis3.2.1 High incidence of female rats than male rats. High incidence of kidney arthralgia than simply arthralgia, sham group.3.2.2 Whether female or male rats, compared with the physiological group, the thymus index in arthralgia group, kidney arthralgia group, the sham group are lower (P<0.05), with statistical significance. Thymus index was the lowest in kidney arthralgia group.3.2.3 Whether female or male rats, compared with the physiological group, the content of IL-1, IL-6, TNF-alpha, TGF-beta in arthralgia group, kidney arthralgia group, the sham group are higher (P<0.05), with statistical significance. The content in kidney arthralgia group are highest.4 Conclusion4.1 The arthralgia can cause lung tissue damage, IL-1, IL-6, TNF-alpha and TGF-beta in the process of lung injury play an important role.4.2 Kidney related lung damage occurs to the joint Arthralgia, Kidney dificiency will increase arthralgia, and arthralgia secondary lung injury.