Study On Inhibitory Effects And Mechanism Of Dangguibuxue Decoction On The Proliferation Of Lewis Lung Cancer

ObjectiveLung cancer incidence and mortality of malignant tumor is the first, thus inhibited the growth of the lung cancer related research is very much also.Dang gui bu xue tang is used in these clinical department such as internal medicine, surgical and gynecology.Summarizes the related research of its,Dang gui bu xue tang can promote angiogenesis, mainly to promote the diseased tissue repair; But to restrain the growth of the tumor tissue related research reports is also rare."Dang gui bu xue tang physical combined early experiments inhibiting cultivation with tumor endothelial cell proliferation and its molecular mechanism of related basis",In lung cancer as the research object,In animal experiments in vivo, research Dang gui bu xue tang inhibited the growth of the tumor related role.MethodSelected experimental tumor Lewis lung cancer, experimental animals choose into C57BL/6 tumor rate is high. Building, grouping is drawed from tumor mouse general life situation, the weight change, tumor mouse tumors volume change, inhibitory rate, pulmonary metastases number, thymus index, spleen index, mice serum GM-CSF level and tumor tissue VEGF content that eight aspects to observe angelica blood tonic soup inhibitory effect on Lewis lung cancer tumors in mice.ResultsMental conditions, feed consumption, temperature and hair gloss in DBD low does group and DBD low does group were significantly better than the rest of the group.,especially in DBD high dose group. This shows that DBD can improve the quality of life into tumor mice. Groups of tumor mice weight curve table show that DBD had the effect of delay tumor mice body weight. In tumors volume index, DBD could inhibit growth of tumor; In tumor inhibitory rate and the number of pulmonary metastases these two aspects,DBD significantly reduced the quality of tumor and also reduced the number of lung metastases; In immunology, DBD not only significantly increase the quality of the spleen and thymus of immune organ, but also significantly increased tumor mice serum gm-csf level, this shows that DBD has increase the immune function of tumor mice; DBD can significantly reduce the expression of vascular endothelial cells of the tumor tissue, had significant statistical differenceConclusion1. Danggui Buxue Decoction could significantly improve the quality of life of tumor mice, suppress tumor growth, Significantly reduce the number of lung metastases.2. Danggui Buxue Decoction could Significantly improve the immune function of tumor mice3. Danggui Buxue Decoction could Significantly reduce the expression of vascular endothelial cells of tumor tissue, and Play a role of inhibiting the growth of tumor blood vessels...