The Correlated Study Between Moxibustion Sense And Moxibustion Effect Through Heat-sensitive Moxibustion Treating Primary Dysmenorrhea

Primary dysmenorrhea refers to dysmenorrhea caused by the non-pelvic organic disease, and it is due to urerine intrinsic dysfunction. It always begins from2or3years after menarche of adolescent girls or young women without childbearing. It takes serious impact on women's physical and mental health because of its high incidence and difficult treatment. There is no satisfactory method with western medical treatment, while acupuncture and moxibustion is widely used for its efficacy, easy to operate, non-toxic side effects. Heat-sensitive moxibustion is an innovative moxibustion method. The key point is its treatment based on sensitivity differentiation. Its capacity for moxibustion bases on individual saturated quantity. It pays attention to channel transmission and maximizes the therapeutic effect of moxibustion through improve moxibustion sense, moxibustion point and moxibustion quantity. This subject will research from literature and clinical Part I:Literature SearchThe first part of the literature systematically discusses the mechanism of primary dysmenorrhea from the point of view of modern medical knowledge, as well as the pathogenesis and therapeutic rules of diseases from the point of view of ancient physicians. It is used to guide the clinical diagnosis, treatment and scientific research. The second part focuses on the theoretical and clinical advances of heat-sensitive moxibustion, interprets and summarizes this innovative theory to find disadvantage and guide the direction of development. The third part introduces the theory of infrared thermal imaging technology, as well as the application in medicine and in acupuncture-meridian research, which makes it possible to apple the infrared thermal imaging to heat-sensitive moxibustion technology.Part II:Experimental studyStudy one:The comparative study between moxibustion sense and infrared thermal imaging through detecting heat-sensitive Guanyuan of primary dysmenorrheaObjective:Primary dysmenorrhea patients are studied. Through the comparative study between moxibustion sense and infrared thermal imaging, detects the sensibility(true positive rate), specificity(true negative rate) and veracity of infrared thermal imaging, provides objective basis for moxibustion sense can be objectively displayed by infrared thermal imaging from a certain extent.Methods:80primary dysmenorrhea cases were studied. Moxibustion sense method make thermal diffusion or conduction length≥10cm as the Guanyuan area thermal state positive, and vice versa<10cm for the thermal state of Guanyuan area negative. Infrared Method:①The average temperature difference between Guanyuan and control piont ΔF>0.3℃befor operate is positive(calculated automatically by the imaging system, the unit℃), and vice versa<0.3℃is negative.②See the diameter of infrared radiation region (the temperature rises above0.5℃) produced along the abdominal median longitudinal diffusion (Ren) or lateral diffusion (Dai) afer Moxibustion>10cm as the Guanyuan area thermal state positive, and vice versa<10cm for the thermal state of Guanyuan area negative. Calculate the sensitivity (true positive rate), specificity (true negative rate) and accuracy of the infrared heat image method.Results:Under the resting state of heat-sensitive Guanyuan, the majority of the infrared radiation intensity displayed low temperature characteristics. Compared with moxibustion sense method, the sensitivity was75.5%, the specificity was74.1%and the accuracy was75.0%. The heat-sensitized Guanyuan produced obvious infrared radiation region along the abdominal median longitudinal diffusion (Ren) or lateral diffusion (Dai) afer Moxibustion. Compared with moxibustion sense method, the sensitivity of thermal infrared imager was77.4%, the specificity was70.4%and the accuracy was75.0%.Conclusion:Heat-sensitive points in resting state or functional state could be reacted by infrared thermal imaging technology to a certain extent. Infrared thermal imaging technology could be applied to objective display research on heat-sensitive point and provide objective basis for clinical research of heat-sensitive point. Study Two:The correlated study between moxibustion sense and moxibustion effect through heat-sensitive moxibustion treating primary dysmenorrheaObjective:Through observation on the clinical scale scores of patients with primary dysmenorrhea and the detection of experimental data related to dysmenorrhea, detect the effect of heat sensitive moxibustion and the correlation between moxibustion sense and moxibustion effect.Methods:117cases of patients with primary dysmenorrhea were studied. The groups were divided up by the combined method of moxibustion sense and infrared thermal. According to whether the point was heat-senstized, patients were divided automaticlly into heat-sensitized group and non-heat-sensitized group. Treated3courses, follow-up visit3months and writed down moxibustion sense, scale scores and biochemical indicators.Results:①The heat-sensitized rate of Guanyuan point was52.1%in patients with primary dysmenorrhea.②The average days of heat-sensitized Guanyuan was5.17days in the first course,4.27days in the second course and3.06days in the third course.③The average amount of saturated quantity of moxibustion was63.20±16.08minutes in heat-sensitized group.④Though the assessments of symptom scores, McGillPain Questionnaire, COX scale of primary dysmenorrhea, recent treatment results were significant for both heat-sensitized group and non-heat-sensitized group in treating primary dysmenorrhea, heat-sensitized group was obviously better than non-heat-sensitized group; Follow-up of3months, symptoms of heat-sensitized group was not recurrence, while symptoms of non-heat-sensitized group recured. The long-term efficacy of heat-sensitized group was significantly better than the non-heat-sensitized group.⑤Through the detection of PGF2α,PGE2,AVP in primary dysmenorrhea menses, recent treatment results were significant for both heat-sensitized group and non-heat-sensitized group in improvement of PGF2a/PGE2,AVP, but heat-sensitized group was obviously better than non-heat-sensitized group; Follow-up of3months, symptoms of heat-sensitized group was not recurrence, while symptoms of non-heat-sensitized group recured. Reflected by objective indicator, the long-term efficacy of heat-sensitized group was significantly better than the non-heat-sensitized group.Conclusion:The probability of occurrence of heat-sensitive Guanyuan are high related with the state of illness; The saturated quantity of moxibustion is about1hour. The short-term effect and long-term efficacy of heat-sensitized point are superior to non-heat-sensitized point.