Clinical Reseach On Treating Chest Stuffiness And Pains By Applying Replenishing Qi And Blood, Removing Blood Stasis And Eliminating Mass

Object Clinical effect on treating angina pectoris by applying replenishing qi andblood, removing blood stasis and eliminating mass would be observed．Methods68patients in accordance with the inclusion criteria were divided into twogroups according to random number table． Formulas with function of replenishing qi andblood, removing blood stasis were applied in treatment group． Aspirin andisosorbide-5-nitrate tablets were applied in control group which were basic treatment inwestern medicine,100mg per time, one time a day and20mg per time, three times aday respectively． The main symptoms, electrocardiogram, total effective rate and sideeffect of angina pectoris were evaluated12weeks later．Results①Clinical symptoms improvement:23patients were found taking markedeffect(63.89%),11patients effective(30.56%)and2ineffective(5.56%) in treatmentgroup. Total effective rate were94.45%.10patients were found taking marked effect(31.25%),15patients effective(46.88%)and7ineffective (21.88%). Total effectiverate were78．13%． Significant differences could be found in marked effect and totaleffective rate between two groups(P＜0.01).②I mprovement on angina pectoris:22patients were found taking marked effect(61.11%),12patients effective(33.33%) and2ineffective(5.56%)in treatment group. Total effective rare were94.44%．11patientswere found taking marked effec(t34.38%),14patients effective(43.75%)and7patientsineffective(21.88%) in control group. Total effective rate were78．13%. Significantdifferences could be found in total effective rate and marked effect between two groups(P ＜0.05)．③A nalysis on electrocardiogram:3patients were found taking marked effect(36.11%),14patients effective(38.89%) and9ineffective(25.00%)in treatmentgroup． Total effective rate were75.00%.5patients were found taking marked effect(15.63%),10patients effective(31.25%) and17ineffective(53.12%)in controlgroup． Total effective rate were46.88%. Significant differences could be found in totaleffective rate between two groups(P＜0.05).④N itroglycerin dosage:12.82±2.26and2.64±0.89tablets of nitroglycerin were needed before and after treatment respectively intreatment group every week． Significant difference could be found in dosage ofnitroglycerin before and after treatment.11.87±2.67and6.11±1.63tablets of nitroglycerinwere needed before and after treatment respectively in control group． Dosage ofnitroglycerin decreased largely after treatment, but difference weren't found． Dosage ofnitroglycerin decrease largely and its medication stopped in some patients in treatmentgroup．Differences could be found between two group(sP＜0.01).⑤the changes of bloodlipoids: after treatment, the TC, TG, LDL decreased in treatment group and the controlgroup, there was a significant difference (P＜0.01), the treatment group decreasedsignificantly compared with the control group, but there was no difference between the2groups (P＞0.05). The HDL were increased in treatment group and the control group aftertreatment, there was a significant difference(P＜0.01), the treatment group with elevatedlevels significantly compared with the control group, but there was no difference betweenthe2groups(P＞0.05)。⑥the changes of Hs-CRP and Hcy: after treatment, the Hs-CRPand Hcy decreased in treatment group and the control group, there was a significantdifference (P＜0.01).⑦relationship of treatment and type of angina pectoris19patientswith unstable angina pectoris were found taking marked effect(67.86%),8patientseffective(28.57%) and1ineffective(3.57%) in treatment group with28unstable anginapectoris patients． Total effective rate were96.43%.5patients with stable angina pectoriswere found marked effect(62.50%),2patients effective(25.00%) and1ineffective(12.50%)in treatment group with8stable angina pectoris.9patients with unstable anginapectoris were found marked effect(34.62%),12patients effective (46.15%)and5ineffective(19.23%) in control group with stable angina pectoris patients. Total effectiverate were80.77%.2patients with stable angina pectoris were found marked effect (33.33%),2patients effective(33.33%)and2ineffective(33.33%)in control group with6stable angina pectoris patients. Total effective rate were66.67%. Effect could be foundon patients with unstable and stable angina pectoris in treatment group. Differences couldbe found between two groups(P＜0.05).Conclusions Treatment of replenishing qi and blood, removing blood stasis andeliminating mass can be applied in angina pectoris which have no side effect. Its functionalmechanism may have relationship with regulating systolic and diastolic function ofcoronary artery, regulating blood lipid and eliminating atherosclerotic plaque andimproving blood supply of coronary artery.