The Research Of Correlation Between Triggers And Syndromes Of Thoracic Obstruction And Result Of Coronary Angiography

ObjectiveTo investigate the correlation between results obtained through coronary angiography (CAG) and triggers, syndromes of Thoracic Obstruction to provide an objective basis for the prevention and treatment of thoracic obstruction.MethodsThrough a retrospective study of844patients who received CAG and were diagnosed with thoracic obstruction by cardiology department of Jiangsu TCM hospital from2006.7-2011.6, establishing special database with Epidata3.02software, having completed statistical analyses with SPSS17.0software, we observed the frequencies of various triggers to thoracic obstruction and analyzed the correlation between the results of CAG and the top5triggers; We observed the frequencies of various syndromes to thoracic obstruction and the correlation between the results of CAG and the top6syndromes.Results1.531(62.91%) male and313(37.09%) female patients are included in the research, and statistical difference exists in CAG results between the two sexes. The proportion of CAG-positive for male is higher than female (χ2=4.3415P=0.037);2. The age is concentrate on50-80years (83.08); there is a statistical difference between the CAG results and the age, with the age increasing,the proportion of CAG-positive is also increasing before80years old (χ2=13.2216P=0.010)3. The top5triggers of Thoracic Obstruction are fatigue, diet, emotional stress, climate and smoking;4. There is no statistically significant relationship between the CAG results and fatigue (χ2=0.1924P=0.661)5. There is no statistically significant relationship between the CAG results and diet (χ2=0.0949P=0.758)6. There is a statistical difference between the CAG results and emotional distress. The proportion of CAG-positive is higher among thoracic obstruction patients susceptible to emotional stress (χ2=4.1688P=0.041)7. There is a statistical difference between the CAG results and climate, the proportion of CAG-positive is higher for Thoracic Obstruction patients during the winter than other seasons (χ2=4.0482P=0.044)8. There is a statistical difference between the CAG results and smoking, the proportion of CAG-positive is higher for smokers than those who are not (χ2=8.3882P =0.004);9. The top6syndrome groups of thoracic obstruction, in order, are qi asthenia and blood-stasis, Phlegm and blood stasis, asthenia of both qi and yin, vein obstruction of phlegm, stagnant blockade of heart blood, qi asthenia and phlegm-stasis. Among the6groups above, there is an obvious statistical difference in the proportion of CAG-positive (χ2=19.9402P=0.003). Phlegm and blood stasis group has the highest proportion of CAG-positive, which follows qi asthenia and phlegm-stasis group. Among the6syndrome groups above, there is an obvious statistical difference in the count of branch with coronary artery obstruction (χ2=43.9019P=0.001). Phlegm and blood stasis group has the highest risk in three-branch lesion and smallest chance in zero-branch lesion, which follows qi asthenia and blood-stasis group and qi asthenia and phlegm-stasis group.Conclusion1. Sex, age, fatigue, diet, emotional stress, climate and smoking are the important reasons for CAG-positive of Thoracic Obstruction;2. Phlegm and blood stasis are important pathological bases and pathogenesis of thoracic obstruction, the TCM syndrome type of phlegm and blood stasis is a dangerous type of thoracic obstruction.3. Asthenia in origin and sthenia in superficiality is a pathogenesis characteristic of thoracic obstruction. Asthenia of qi and asthenia of yin are pathological basis of thoracic obstruction. Qi asthenia and blood stasis, qi asthenia and phlegm-stasis are dangerous TCM syndrome types of thoracic obstruction.