Acute Cerebral Infarction, Western Profiles And Stroke Refreshing Oral Treatment Of Acute Cerebral Infarction Clinical Research

Objective: l.To provide some helpful imformation to the research, prevention and treatment on stroke or ischemic stroke from both Traditional Chinese Medicine and western medicine; 2. To evaluate the safety and effects of ZhongFengXingNao oral liqid (ZFXN) on acute cerebral infarction, and study its probable mechanism. Metheds: 1. Consulting TCM ancient books and records about stroke; Using the Chinese Medical Retrieval Optical Disk and MEDLINE database search the correlated documents of the latest ten years; 2. 55 patients with acute atherosclerotic cerebral infarction, including 28 treated with ZFXN were enrolled in a randomized controlled trial for assessment on ZFXN. The neurologic deficit were measured using NIHSS and MESSS, and the disability or activity, using BI. The primary outcome measure were the mortality rate, the percentage of patients dead and with disability, and the percentage of patients with minimal or no disability at 90 days. The hemorheology, PT, APTT and blood-lipide were also meartured, and all the side-effects were recorded. Results: 1. The understanding of the disease, stroke, is having been unified in TCM, including its name, diagnosis, cause, and the pathogenesis. Now most clinicians regard endogenous Feng (wind) as the fundamental cause and the pathogenesis included Xu (deficiency), Phlegm and Blood Stasis, Feng (wind) and Huo (fire), and maybe Toxin. Many formulae and TCM patent medicine were reported with very good effects on ischemic stroke in clinical study or practice. Prevention have always been payed relatively much attention. 2. Many studies were conducted on pathophysiology, diognosis techniques and treatment of ischemic stroke in the latest 10 years and great progress were achieved in these domains. Thrombolytic therapy in early acute stage were established but all the neuroprotective agents' effect was not identificated. A series of guidelines on treatment and prevention were published to provide recommendations for clinicians. The Organized Stroke Care was raised and in establishing to unite prevention, first aid, diagnosis, treatment, rehabilitation and education of stroke to generally lower the in incidence rate, mortality rate and mutilation rate of ischemic stroke. 3. In ZFXN group, the improvement of neurologic deficit was significantly greater at both 30 and 90 days, and the percentage of patients with minimal or no disability at 90 days was significantly higher comparing with that in controlled group; the hemorheology of patients were also improved; no important side-effects was observed. Contusion: 1. The TCM ancient books and records about stroke were abundant and detailed which was worth inheriting. RCTs should be performed to confirm the curitive effects of formulaes which have showed potential effects in clinical practice. 2. Thrombolytic therapy can not benefit most ischemic stroke patients now due to its strict indication, so more study should be conducted to screen new effective therapy or try to extend the time-window. 3. ZFXN can significantly improve the neurologic deficit and activity of daily life of patients with acute atherosclerotic cerebral infarction without obviously side-effects. Its curitive effects probably is oweing to the improvement of hemorheology.