Advanced Non Small Cell Lung Cancer Chemotherapy Medicine Involved In The Treatment Of Retrospective Clinical Study

Primary bronchial lung cancer is one of the most common malignant tumors. Its 5-year survivalrate is less than 15%. Among which, 80% are non-small-cell lung cancer (NSCLC), 75% of patientsare in the advanced stage (stage IIIB or stage IV) when diagnosed, missing the opportunity of aradical operation. The multimodality therapy is recommended at present; its aim is to improve thequality of life and extend survival time. Literature shows that the intervention of Chinese medicine in the perichemotherapeutic stage ofadvanced NSCLC can minimize the toxic and side effects of chemotherapy, increase chemotherapycomplete rates and remission rates, relieve symptoms and improve quality of life. However, due tothe lack of polycentric, big sampling, and standardized clinical data, there are still no enough evidenceto prove the advantage of TCM intervention and instruct standardized treatment. This study initiallyattempted to conduct a clinical retrospective comparative study of the 211 advanced NSCLC casesadmitted in 7 first-grade, first-class Beijing hospitals from January 1998 to December 2003. 106 casesof which belong to the western medicine (WM) group and 105 cases belong to the integrated TCMand western medicine (integratedTCM andWM) group. Results show: ①comparison of pre-treatment basal information show that the patients of theintegrated TCM and WM group are relatively older, among which 68.98% are senior patients; thescores of KPS are significantly lower than that of the WM group; also, more patients havecomplications such as pain and anemia. ②Evaluation of immediate effects show that both groups donot have complete response (CR) cases; as for the partial response (PR) cases, there are 39 for theWM group (37.14%) and 23 for the integrated TCM and WM group (21.90%); for stable diseasecases, there are 42 for the WM group and 66 for the integrated TCM and WM group, 40% and62.86% respectively; for progressive disease cases, there are 24 for the WM group and 16 for theintegrated TCM and WM group, 22.86% and 15.24% respectively. The CR+PR of both groups showsignificant statistical difference (P<0.05), where in the WM group proves to be better than theintegrated TCM and WM group; the CR+PR+SD of both groups show no significant statisticaldifference (P>0.05); when evaluating the PD cases of both groups, the percentage of the WM groupis higher than that of the integrated TCM and WM group. ③the quality of life (QOL) evaluationproves that the post-treatment integrated TCM and WM group has a significant increase in the scoresof KPS, the percentages of increase in the scores of KPS are 16.04% and 60.00%, WM group andintegrated TCM and WM group, respectively; the percentages of constancy are 64.15% and 37.17%,WM group and integrated TCM and WM group, respectively; the percentages of decrease are19.81% and 2.86%, WM group and integrated TCM and WM group, respectively. The scores of KPSof both groups show very significant statistical difference (P<0.0001), proving that TCM interventionin treatment can improve the quality of life of patients. ④The chemotherapy complete rates (CCR)are 83.02% and 87.62% for WM group and integrated TCM and WM group, respectively, showing英文摘要 ·3·no significant statistical difference (P>0.05). ⑤Toxic and side effects such as bone marrowdepression and gastrointestinal disturbance caused by chemotherapy showed no significant statisticaldifference in both groups. ⑥When advanced NSCLC is diagnosed, clinical symptoms arecomplicated. After statistical factor analysis, results show that majority of the symptoms implydeficiency of qi and yin. Besides, greasy tongue coating occupy and high percentage of 48.57%,meaning phlegm or phlegm-dampness is significant in the development of lung cancer. ⑦Accordingto the analysis of tongue, pulse, and symptoms, the deficiency of qi and yin (37.14%) and thestagnation of phlegm and bl...