Gastric Precancerous Lesions Tcm Syndrome Characteristics And The Mechanism Of Wilt Capsule

Gastric precancerous lesions is the potential benign lesion of gastriccarcinoma.Chronic atrophic gastritis(CAG)and intestinal metaplasia (IM) ordyspalsia(Dys) due to CAG are the commonest of gastric precancerous lesions.Since thecause of gastric cancer is not very clearly,and casual prophylaxis is difficult to carryout,it becomes more imperative to study on ganstric precancerous lesions and to find outits prophylactic therapeutic measures. We discuss the cognition of traditional Chinese medical syndrome of ganstricprecancerous lesions and therapeutic mechanism through three ways of the theoreticalstudy,clinical research and experimental study ,trying to explore a better way for thetreatment of ganstric precancerous lesions.THEORETICAL STUDY: The law of syndromes of gastric precancerous lesions(painful abdominal mass)wasdiscussed by investigating the related literature in ancient times systemically. MentorTianDelu's scienticfic thought on gastric precancerous lesions was summarized.CLINICAL RESEARCH: Methods:According to the methods and principles of clinical epidemiology, weobserved the 286 patient's clinical case provided by multi-hospitals in Beijing and tostudy the traditional Chinese medicine(TCM) syndrome pattern of gastric precancerouslesions by the fator analysis and logistic regression analysis methods. Results: 1.Using the fator analysis, 8 TCM syndromes of gastric precancerous lesions weresummarised: para-deficiency of spleen-yang, para-damp heat in the spleen and stomach,para-blood stasis with deficiency in kidney, para-qi deficiency of the spleen and stomach,para-stagnation of stomach-qi, para-liver heat and defiency of the spleen, para-deficiencyfire due to insufficiency of stomach-yin, para-intermixing chills and fever. 2.There was no significant statistical difference in the sex, age, diet, causative factorover the classification of the TCM syndromes (P>0.05). 3.There was significant statistical difference in the mucosal color andvasoganglion under gastroscope over the classification of the TCM syndromes (P<0.01).The result showed the syndrome of para-damp heat in the spleen and stomach had mostsamples of red gastric mucosa.Para-damp heat in spleen,stomach and para-deficiency ofspleen-yang and para-blood stasis with deficiency in kidney are the common syndrome inthe red and white. Para-qi deficiency of the spleen and stomach was the commonestsyndrome in the white.Para-deficiency of spleen-yang was the commonest syndrome inthe hoariness or grey.4.There was no significant statistical difference in the Mucosal edema,anabrosis,coarseness,bile back flow,with superficial gastritis over the classification ofthe TCM syndromes (P>0.05). 5.There was significant statistical difference between the patient who infected byhelicobacter pylori and non-infected over the classification of the TCM syndromes (P<0.01). 6.There was significant statistical difference in the different level of gastricprecancerous lesions over the classification of the TCM syndromes (P < 0.01).Para-damp heat in the spleen and stomach, para-deficiency of spleen-yang,para-qideficiency of the spleen and stomach, para-deficiency fire due to insufficiency ofstomach-yin were the main syndromes of lower level. Para-blood stasis with deficiencyin kidney, para-deficiency of spleen-yang, para-damp heat in the spleen and stomachwere the maine syndroms of middle and higher level. 7.There was significant statistical difference between CAG and CAG with IM orDys over the classification of the TCM syndromes (P<0.01).Binary logistc regressionanalysis showed that para-stagnation of stomach-qi and para-deficiency fire due toinsufficiency of stomach-yin had significant correlation with CAG.(P=0.020,OR=3.238& P=0.027,OR=2.732) 8.There was significant statistical difference between CAG with IM and without IMover the classification of the TCM syndromes (P<0.01).Binary logistc regressionanalysis showed that para-deficiency of spleen-yang and para-blood stasis withdeficiency in kidney had significant correlation with IM(P=0.030,OR=3.170 &P=0.014,0R...