Relevant Reserch On HP, Tiam1 And Nm23H1 Protein Expression On Gastric Cancer And Precancerous Lesion

[objective] Application immunohistochemical Max - Vision detecting method, 1.Atrophy of atypical and stomach of HP infection and Tiam1, nm23H1 expression. 2 .a group in the same case Tiam1 before nm23H1 and HP radical changes in the expression. 3 HP infection, and discusses Tiam1 nm23H1 benign lesions in gastric mucosa and stomach occurrence, development process, which is helpful for further discussion correlation invasion and metastasis of cancer of the stomach, molecular mechanism for early diagnosis and biological treatment.[materials and methods] Collect yan'an pathologists university school of medicine in January 2006-2008 between October archived histopathological wax, the postoperative radiotherapy and chemotherapy, without the experience of pathology confirmed physicians. Superficial with atrophic gastritis with 85 cases, atrophic gastritis im 74 cases, atrophic gastritis with atypical 98 cases, benign gastric mucosal lesions 257 cases, including total eradication therapy to the HP (+) cases of 90 cases.Immunohistochemical Vision method, HP Max - by methylene blue dye detection.[result] 1. HP infects the expression of Tiam1 and nm23H1 in all kinds of gastric mucosal tissues1.1 In gastric mucosal lesions with atrophy and atrophy of superficial group with im and stomach HP Tiam1 positie cases of positive and negative expression rate of positive cases comparison HP the difference was not statistically significant (P > 0.05). Atypical HP Tiam1 positie cases of the positive rate of expressing negative significantly higher than the masculine expression HP cases (P < 0.05).1.2 In the stomach, benign lesions in the group with atrophy, atrophy with superficial bowel and atypical HP nm23H1 positie cases of the positive rate of expression is significantly higher than that in group HP (P < 0.05). Positive and negative gastric HP nm23H1 cases of expression there was no significant difference (P > 0.05).2 HP (+) Tiam1 nm23H1, after cure cases of gastric mucosal tissue in the expression2.1 In the superficial companion atrophy, atrophy of gastric mucosa with bowel lesions HP (+) cases cure Tiam1 before the positive rate of expression in the group with radical after comparison between masculine expression rate no significant difference (P > 0.05). In atypical of gastric mucosal lesions HP (+) cases cure Tiam1 before the positive rate of expression is significantly higher than that of the positive rate of expression after radical (P < 0.05).2.2 In the superficial companion atrophy, and atrophy with bowel, atypical gastric mucosal lesions HP (+) cases cure nm23H1 before the positive rate of expression is significantly higher than that of positive expression after radical groups (P < 0.05).3 .The relationship between clinical pathology characteristic of gastric Tiam1 and nm23H13.1Tiam1 protein in stomach tissue the expression level and gender, age, disease primary site was not statistically significant (P > 0.05), but with gastric cancer tissue, infiltration depth differentiation, lymph node metastasis Tiam1 significant positive correlation, protein is increasing trend of dyeing rate between groups, compared with significant difference (P < 0.05).3.2Nm23H1 protein in stomach tissue (the expression level and gender, age, disease in each primary site is no statistical difference between staining (P > 0.05), with gastric cancer, but the differentiation of organization, the infiltration depth, lymph node metastasis nm23H1 significant positive correlation, protein is gradually reduce dyeing rate between groups, compared with significant difference (P < 0.05).4 .Tiam1 and nm23H1 are the negatively correlated expression[conclusion] 1. In stomach tissue of the expression with gastric cancer tissue, the differentiation of the lymph node metastases, infiltration depth deepens obviously increased.2.Nm23H1 in stomach tissue, and the expression of low degree of cancer of the stomach, lymph node metastasis and infiltrating pathological differentiation degree.3. Hp infection may make atypical organization, Tiam1 expression of Hp to eradicate after treatment with atypical organization Tiam1 expression is abate.4 .Hp infection can make nm23H1 with atrophy, atrophy in shallow with bowel, and atypical organization of Hp to abate, the expression nm23H1 can make eradication therapy.