Red Drug Chemical Composition And Biological Activity Of A Preliminary Study

Hongyao, the whole plant of Chirita longgangensis W. T. Wang var. hongyao S. Z. Huang, is only distributed in China. It had been used as folk herbal drugs in the south of China, especially in Guangxi province. Hongyao, slightly sweet and puckery in taste and neutral in nature, has the function of warming and enriching the general blood, easing pain. It can be used for the treatment of the Women's disease and be used as analgesic and detumescence crude drugs. The methanol extract of Hongyao could decrease the degree of body torsion of mouse caused by acetic acid and possed some analgesic effects. The extract could be benefit for the cure of anemia. The records on the systematical chemical and pharmacological researches of Hongyao have not been reported as yet till now. Through the study of chemical constituents of this plant only distributed in China can probably provide new bioactive compounds.In our phytochemical research of the stem of Chirita longgangensis W. T. Wang var. hongyao S. Z. Huang, 25 compounds and a new diastereomeric pair of compounds have been isolated and 24 of these compounds and the diastereomeric compounds have been identified by modern spectroscopy such as ESI-MS, FAB-MS, 1H-NMR, 13C-NMR, 1H-1HCOSY, HMQC, HMBC and so on. Among the compounds that have been identified, there are one a -Dunniones: 7-Hydroxy-2,3-dihydro-2,3,3-trimethylnaphtho[2,3-b]furan-4,9-dione (HY1); one β-Naphthalenecarboxylic acids: 1,4-Dihydroxy-2-naphthalenecarboxylic acid methyl ester-4-O-β-L-Rhamnopyranosyl-(1→6)-β-D-Glucopyranoside(HY2); two C-Glycosylflavones:2(R)-Eriodictyol-8-C-β-D-glucopyranoside(HY3a),2(S)-Eriodictyol-8-C-β-D-glucoyranoside(HY3b); five Phenylethanosides: 3,4-Dihydroxyphenyl alcohol- β -D-glucopyranosyl-(1 → 3)-6-O-feruloyl-β --D-glucopyranoside (HY4), 3,4-Dihydroxyphenyl alcohol- β -D-glucopyranoside (HY5), 3,4-Dihydroxyphenyl alcohol-6-O-caffeoyl- β -D-glucopyranoside (Calceolarioside B) (HY6), 3,4-Dihydroxyphenyl alcohol-β -D-glucopyranosyl-(1 →3)-6-O-caffeoyl- β -D-glucopyranoside (Plantainoside D) (HY7), 3,4-Dihydroxyphenyl alcohol- β -D-glucopyranosyl-(1 →3)-4-O-caffeoyl- β --D-glucopyranoside (Plantamajoside) (HY8); one Lignans:3',4',9,9'-Tetrahydroxy-4,5-dimethoxy-2,7'-cyclolignan (HY9); two...