| Abdominal aortic aneurysms (AAAs) represent a common vascular condition with life-threatening implications. Although basic research has led to a better understanding of aneurysm disease in the past two decades, fundamental knowledge about the process of aneurismal degeneration remains limited. The prevalence of AAAs is relatively high in the general population, and current clinical options are somewhat limited, making it apparent that an urgent need for investigating the cellular and molecular nature of aneurysm disease.As we all know, aneurysm degeneration is the end result of a multifactorial process leading to the destruction of aortic wall connective tissue. The most important structural elements in the aortic wall are elastin and intestitial collagens . Although disruption of medial elastin is a particularly prominent feature of AAAs, the changing of interstitial collagens plays an important role in aneurysm degeneration.We examined the levels of mRNA of al chain of type III collagen(col3a1), Human collagenase-3(MMP13), tissue inhibitor of metalloproteinase-1(TIMP1) and TIMP2 in AAA(n=5),and normal aorticcontrols(n=3) by using the reverse transcription-polymerase chain reaction(RT-PCR).We found that the levels of col3al, MMP13 and TIMP1 were increased in the AAA group compared with those in normal group(P<0.05). Only in the case of TIMP2 was not statistically significant between them(0.05 |
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