Forsythia Volatile Oil Anti-inflammatory Effects And Mechanisms,

Forsythia suspensa(Thunb) Vahl is a kind of commonly used Chinese herb which belongs to the category of treating hot evil.VOFS is one effitive component which is used to decrease the diseases associated with inflammation.However,there is few pharmacological researches about its anti-inflammatory function and mechanism overall. According the theory of TCM,the anti-inflammation function and mechanism of VOFS is firstly studied from the level of entire animal,cell and molecule,by means of advanced modern technology such as analysis,immunohistochemistry,ELISA, portrait analysis ect.The results of the experiments showed:1.VOFS had a good effect of anti-inflammation:It exhibited definite anti-inflammation effects on chronic and acute animal models.It proved that the anti-inflammation effect of VOFS is significant and clear-cut.VOFS is one of the primary substantial basis of its treating hot evil2.VOFS had a good effect of relieving pain: Painful mice by hot plank and acetic acid can be treated by VOFS.It suggested that VOFS had the fuction of relieving pain following to inflammation, Which is advantageous to anti-inflammation.3.The realization of anti-inflammation of VOFS is not by enhancing the function of HPA.The anti-inflammatory mechanism of VOFS is as follows: â‘ Decreasing the production of PGE₂ in the process of COX,and inhibiting the production of histamine and 5-HT also .â‘¡Inhibiting the free-radical production such as NO,MDA,and increasing SOD. â‘¢...