Temperature Dismount Immune Injury Mechanisms Of Temperature Astringent Treatment Of Ulcerative Colitis

Background and ObjectiveUlcerative colitis (chronic nonspecific ulcerative colitis) is a disease of digestive tract characterised by chronic inflammation and ulceration of colonic mucous membrane. Clinical manifestation: mucus, pus and blood stool;diarrhea; abdominal pain; tenesmus and so on. Etiopathogenisis and pathogenesis of the disease is not very clear. At present, aminosalicylic acid, cortex steroid hormone and immunomodulator is the effective western medicine.In active stage of ulcerative colitis,these medicine can quickly control the symptoms.The clinical remission rate is high.But the disease is easily recur after drug withdrawal.And side reaction is multi with long-term medication.These medicine are not ideal to intractable cases. Chinese medicine has remarkable preponderance in treating this disease and is obviously superior than weastern medicine in total curative effect.Professor Tian Delu,my tutor who studies UC based on the theory of Traditional Chinese Medicine and Modern Medicine, believes that UC is most similar to relapsed dysentery according to alterating syndromes and manifestations in episode period and remission period. And the mechanism of UC can be summarized that deficiency in spleen is its root while moist heat is its end, and its local phathology is characterized by blood stasis while inner ulcer is its phathologic manifestations. As for treating methods and principles, Professor Tian summarizes that invigorating the spleen and benefiting vital energy is the method of treating the root clearing heat to removing dampness and toxic materials is the usual method of treating the appearance, activating blood circulation to dissipate blood stasis is the usual treating method of paracmasis and recidivist due to invalidism and removing necrotic tissues and holding sore to promote regenearation of tissues is the key of local treatment.Professor Wang Xinyue, who inherited from Professor Tian, believes that different therapy be used properly in different periods of UC. Mostly, the methods of warm and purgation and warm and unsmooth are usually used in clinic. However, purgation and unsmooth are both concepts opposed each other in TCM, and how to use both methods properly so as to improve effect of therapy and degrade relapse rate is the key point of treatment.The topic is begin with the mechanism of immunologic injury.We deeply approach the mechanism of warm and purgation and the warm and smooth methods in treating UC from the aspects of regulating cellular immune function,restraining the reaction of inflammatory injury, promoting the repair of colonic mucous membrane,repressing recur...