Modulation Of The Hippocampus And Morphine On Noxious Stimuli By Thalamic Nuclei Uplink Pass

Previous studies by various authors have shown that the second somatic area(S2) of cerebral contex serves as the center of perception of pain. Peripheral pain stimulation is transmitted to S2 via the posterior necleus group of the thalamus (Posterior group nuclei, PO). which has been shown to be closely related to pain sensation. It is an important integrating center of pain sensation, as well as a relay of the nociceptive stimulation input to cerebral cortex along the afferent pathway in the following order, peripheral afferents → spinal cord → PO → S2.Hippocampus is an important part of limbic system, it receives the nociceptive stimulation arising from visceral and somatic nerves. A lot of publications reported the relevance of hippocampus to learning, memory, pain perception and emotion. Pain almost always evokes the changes in emotion, while changes of emotion can at times affect pain perception. It has therefore been speculated that hippocampus may be involved in the transmission of pain sensation and thus affect its perception.