| Strenuous exercise or other stress conditions often predispose coronary artery disease events. To assess the changes of endothelium function, fibrinolytic activity and platelet activation in patients with coronary artery disease, and their relations to extent of ischemic area and severity of coronary artery lesions, 37 patients with coronary artery disease confirmed by coronary angiography( Group CAD ), including 15 with multivessels lesions ( Group M ) and 22 with single vessel lesion (Group S ) and 27 healthy persons selected as control (Group C ) , all underwent symptom free multistage treadmill exercise test. During pre and peak exercise, blood samples were taken for the following parameters: ( 1 ) activities of plasminogen activator inhibitor-1 ( PAI-1 ) and tissue-type plasminogen activator ( t-PA ); ( 2 ) plasma concentration of 5-HT, 5-HT2 receptor specific binding and platelet intracellular free calcium concentration; ( 3 ) plasma concentration of endothelin-1 ( ET-1 ).Result: (1 ) Before exercise, PAI-1 and t-PA activity were higher in Group CAD, as compared to Group C (P < 0.025 ), PAI-1 was higher in Group M than Group S, but no significant difference of t-PA activity between these two groups. After exercise, t-PA activity in Group C was significantly higher than that before exercise (P < 0.005 ), but in Group CAD it was lower than that before exercise (P < 0.05 ), even lower than that in Group C ( P < 0.05 ). PAI-1 activity in Group CAD was prominently higher than that before exercise ( P < 0.025 ), Group M was higher than Group S (P < 0.025 ). ( 2 ) Before exercise, plasma level of 5-HT in Group CAD was higher than that in Group C ( P < 0.05 ), no difference between Group M and Group S. After exercise, in Group S there was no much change, while in Group M, it was significantly higher ( P < 0.025 ). 5-HT2 receptor specific binding in Group CAD, before exercise had tendency to increase as compared with that in Group C;...
|
PDF Full Text Request