Securinine Total Synthesis

Securinine 1 was synthesized with α-ketol 2 as the starting material by acetylation, bromination, eliminationand condensation. The final product was identical with a natural specimen by comparing their IR, HNMR and melting points.As a relay the α-ketol 2 was obtained by degrading natural securinine instead of a multi-step synthesis Thus this work constitutes a formal total synthesis of securinine.α-Ketol 2 was an important intermediate in the procedure of the total sythesis of securinine. Its synthesis was explored at first with allyl bromide and diethyl malonate then with cyclohexenone as the starting materials.