Association Between Carotid Atherosclerosis And Blood Stasis Syndrome

OBJECTIVE: According to the new theory of"the conception and attribute of the sndyrome", this study is to observe the relationship between the Blood Stasis Syndrome(BSS) defined by Chinese medicine with carotid hemodynamics, carotid atherosclerotic plaques(CAP) and atherosclerotic relative active substances, to look for correlation between atherosclerosis(AS) with BSS.METHODS: 209 patients were selected from 306th Hospital of The Chinese People's Liberation Army .All subjects comprised 136 patients with acute cerebral infarction(CI) and 73 volunteers without acute cerebral infarction. All patients were examined color dopplor ultrasound for hemodynamics ,IMT and CAP of carotid artery. Morever,ELISA way was used to test the levels of MMPS-9,TIMP-1,b-FGF , Hs-CRP and blood-lipid in blood-serum in CI patients.RESULTSL1)The correlation between BSS and carotid hemodynamics:â… .The carotid diameter, intima-media thickness(IMT) of BSS group is more than none- Blood Stasis Syndrome(NBSS) group(P <0.01/0.05). and also the carotid velocity, Resistance indexes(RI), Pulsatile indexes(PI) of several carotid artery in BSS group is more than NBSS group(P <0.01/0.05),but the carotid velocity of several carotid artery of BBS group is less than NBBS group (P <0.01/0.05).â…¡:There is correlation between carotid diameter, AS, diastolic velocities of several carotid artery with BSS(P <0.01/0.05).contraily, systolic velocity of several carotid artery, PI has a negative correlation with BSS(P <0.01/0.05).(2) The correlation between BSS and CAP:â… .The frequency of ulcerative CAP in BSS group is higher than NBSS group(P <0.05).The frequency of ulcerative and heterogeneous CAP in patients with BSS and CI are more than those patients without BSS have CI(P <0.01/0.05). There is correlation between the quantity of CAP and ulcerative CAP with BSS(P<0.05).â…¡.Carotid atherosclerotic stenosis(CAS) and the quantity of CAS in BSS group is more than NBSS group (P <0.01/0.05). The frequency of CAS in patients with BSS and CI are much more than those patients without BSS have CI(P <0.01). There is significant correlation between the quantity of CAS and CAS with BSS(P<0.01).(3) The correlation between BSS and atherosclerotic relative active substances:The levels of MMP-9 in blood serum in patients with CI have BSS is much more than those patients without BSS have CI(P<0.01). There is significantly correlation between MMP-9 with BSS(P<0.01).Comparing to NBSS group, the levels of TIMP-1,b-FGF and Hs-CRP in blood serum in BSS group are no significantly difference(P >0.05). There is no signifantly difference between TIMP-1,b-FGF , Hs-CRP, blood-lipid with BSS(P >0.05).CONCLUSIONL1)The patients with BSS have AS. (2)There is correlation between carotid diameter,the number of CAP and ulcerative CAP with BSS.Morever, the CAP in patients with BSS have unstablity. The number and unstablity of CAP increased in patients with BSS have CI.(3) The carotid diameter of patients with BSS have increased,and also the patients with BSS have CAS and abnormal carotid hemodynamics. The carotid diameter,the degree of CAS and number of CAS increased in paitents with BSS have CI.(4)There is correlation between MMP-9 with BSS.Contrarily,there are no correlation between TIMP-1,b-FGF , Hs-CRP, blood-lipid with BSS.