The Huanglian Wendan Tonga Taste Treat The Elderly With Mild Cognitive Impairment In Clinical Research And Evaluation Of Clinical Efficacy

1.Clinical researchIntroductionIt is effective measure to intervene actively senile Mild Cognitive Impairment for deferiing decline of cognitive function.In other words,dementia was delayed.It is great academic and realistic significance to relieve family and social burden.ObjectiveTo observe the clinical efficacy of Coptis Decoction for Clearing Away Gallbladder-heat on thetreatment in the elderly with mild cognitive impairment (MCI).MethodsThe research design principle was block random,double-blind and controlled.64 patients with MCI were selected and were randomly assigned into a treatment group (30 cases),given 200ml of compound Chinese herb with 2 grain placebo,and a positive control group(30 cases),given 2 grain of Aniraectam capcle with 200ml placebo,The capsule was taken 3 times and the compound Chinese herb was taken 2 times a day.All subjects took this medication for 3 months.At the starting point and a point after 3months,all subjects were assessed by MMSE,syndrome,DSR,ADL,Ach,and SOD,et cl.ResultsMMSE score was increased from 24.81±1.69 at starting point to 27.22±1.87 at the point of after 3 months of the treatment in the treatment group,which was significantly higher than that in the control group(P<0.01).Ach score was significantly increased from 11.40±6.12 at Starting point to 21.43±9.72 at the point of after 3 months of the treatment in the treatment group,which was significantly higher than that in the control group(P<0.05).The total score of syndrome was increased in the treatment group,significantly higher than that in control group(P<0.05).The score of MMSE,syndrome,Ach In the treatment group was higher than that in the control group on syndrome,MMSE,Ach(P<0.05).ADL,DSR,SOD,MDA score was increased after 3 months of the treatment In the treatment group(P<0.05),but the score In the treatment group was not higher than that in the control group on syndrome,MMSE,Ach.ConclusionThe effect of Coptis Decoction for Clearing Away Gallbladder-heat is superior to Aniraectam capcle's on syndrome,MMSE,Ach.Both Coptis Decoction for Clearing Away Gallbladder-heat and Aniraectam capcle have protective effect on memory decline,ADL,SOD and MDA in elderly with MCI.2.Evaluation of therapeutic efficiencyThe 12 documents all mentioned random in this research,but only two studies described the methods of generating random sequence,and so on.The quality of most of these documents is lower.The results of SR indicate that traditional Chinese medicine used in existing research is mainly in compound,and the primary therapy is tonify the kidney.In addition,tonifying qi and activating blood are also applied.Evaluation of therapeutic efficiency give priority to neuro-psychological measurement scale and Social and functional life scale,such as MMSE,FAQ.It is showed that therapeutic efficiency of TCM treatment group is quite effective for improving cognition in senile Mild cognitive impairment than control group,but there was no difference in the social life function.