Study On The Induction Of Immune Tolerance In Rat Kidney Transplantation By Antilymphocyte Serum Combined With Tacrolimus

Objectives:To induce immune tolerance in recipient rats of allogenic kidney transplantation with antilymphocyte serum combined Tacrolimus. Methods:A model of renal transplantation was established.Receptors were fed Tacrolimus,then ALS were injected.Renal transplantation was performed within the same day.The survival days of receptor rats were observed.Serum creatinine was measured and color Doppler flow imaging was checked.The immunologic tolerance status of rat renal allografts was detected by DTH.Results:The survival days of receptor,the levels of Serum creatinine,the color Doppler flow imaging and the DTH showed that the difference was significant between case group and other three control groups.Conclusion:The antilymphocyte serum combined Tacrolimus can induce immune tolerance from allograft.