Clinical And Experimental Research. Winter And Even The Capsule To Improve Type 2 Diabetes Islet ¦Â-cell Function

Diabetes Mellitus,especially the the 2 type of Diabetes Mellitus is the common diseases in elderly people.Recently years,the study on theβ-cell function has attracted more and more concern.The Donglian capsule is made of Ophiopogonis Tuber Polysaccharide and rhizoma coptidis alkaloids,and just for the TCM syndrome type of yin deficiency inner heat.It can improve the glyeolipid metabolism disorder,prevent and treate Diabetic Complication of Blood Vessels,like Diabetic Nephropathy(DN) and Diabetic Retinopathy(DR).This paper is working on the base of the Previous studies,we observed the effects of the Donglian capsule onβ-cell function and local Endocrinal environment,and investigated its possible mechanisms.PartⅠClinical researchObjective:Observing the effects ofβ-cell function made by the Donglian capsule on the 2TDM with yin deficiency inner heat.Methods:The 90 2TDM with yin deficiency inner heat patients were divided into 2 groups randomly.The therapy group had 43 cases,treated with the Donglian capsule,the control group had 47 cases,treated with metformin hydrochloride.After two weeks basic treatment,the experiment lasted 8 weeks.Compare the effects with metformin hydrochloride,the indexs including liver function,kidney functions,blood glucose, blood lipid,insulin,c-peptide.Calculating the index of insulin resistance and the HomaβCell Function Index.Observing the preliminary situation of theβCell Function in 2DM patient with Donglian capsule.Result:The Donglian capsule can improve the traditional Chinese medicine symptom efficacy,improve the disease effect,reducing the fasting blood glucose,2 hour postprandial blood glucose,reducing the Total Cholesterol,improving the lipid metabolicdisorder.Making theβcell secreted more insulin and c-peptide.Conclusion:The Donglian capsule can improve clinical symptoms,reduce the blood glucose,reduce the TC,improve the blood glucose and lipid metabolism disorder, improve the level of INS,C-P and HBCI,reduce IRI.It has a better therapeutic effects. PartⅡExperiment researchObjective:To investigate the effects of the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids(OP & RA,the donglian capsule) onβcell function in experimental diabetic rats.Methods:The rats models of insulin resistance in 2 type diabetic were established by injecting low dose of streptozotocin(STZ) in 60 high fat-fed SD rats.After one week,the successful models were randomly divided into 4 groups:untreated group(n=7),high OPRA-treated group(n=9),low OPRA-treated group(n=8)and metformin-treated group(n=9),Meanwhile,a normal control group(n=10) was designed.After four weeks, the differences infasting blood glu-cose(FBG),serum lipid,pancreas glucagon(PG), insulin(INS),C piptide(C-P) and Insulin-Like Growth Factor I(IGF_I)were compared among the groups.The expressed area of the islet amyloid polypeptide(IAPP) and resistin, Homa-B Cell Function Index,the Insulin Resistance index are also be compared,too.Results:The OPRA can significantly reduce the level of serum TC and fasting blood glucose,increase the serum insulin,C-P and HBCI,reduce the IRI,increse the IGFI, increse the expressed area of the IAPP,induce the the expressed area of the resistin.Conclusion:The Combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids can increase the secrete of insulin and reduce the secrete of PG.It can propect theβcell function,maybe through the way of alleviating the insulin resistance in pancreas islet,includingαandβcell.