Nourishing Liver And Spleen, Dispersing Phlegm Tongmai Treatment Of Nonalcoholic Fatty Liver Disease

BACKGROUND:Medical knowledge of the fatty liver started from 1842 W. Bowman, the data was mainly from the liver biopsy pathology report.1986, F. Schaffner introduced fatty liver disease (Fatty Liver Disease. FLD). FLD is that the main lesion of the liver cells lie in the lobular steatosis and fat piling up. When lipid accumulation in liver cells more than 5% liver wet weight, or 1/3 of fatty degeneration of liver cells per histological unit, FLD includes simple fatty liver, fatty hepatitis, fatty liver cirrhosis. As developping of social and economic and people's living situation, the prevalence of fatty liver disease and its related diseases showed an upward trend year by year, and become younger, the incidence rate is about 5%-10% in the population, incidence rate are 25% to 75% in those with alcohol, obesity, diabetes, the diagnosis and treatment has become increasingly concerned about public health problems.the detection rate of Chronic fatty liver diseaseis 25% in Western Europe, Japan, the United States. FLD has become the largest chronic liver disease and the leading cause of abnormal liver enzymes in Western Europe, the United States, Australia, Japan. The average adult prevalence of NAFLD is as high as 20% to 33%, of which at least 10% to 15% are non-alcoholic steatohepatitis (NASH), of which 15% to 25% develops cirrhosis after 10 years, and fatty liver sclerosis, hepatocellular carcinoma, liver function failure and liver transplantation. the incidence of simple fatty liver (60%-90%), NASH (20%-25%) and cirrhosis (2% to 8%) in those with obesity.15 years ago, the incidence of fatty liver in China is still quite low. Zhongshan Hospital, Shanghai Medical University, according to Liu Dezhen statistics,220 cases were found fatty liver in the Institute and other units of the 10,923 people in 40 medical examination, the average rate was 2%. As people's living standards improves in recent years, the gradual increase along with the changes in people's diet, physical activity decreased, the average weight gain, fatty liver prevalence rate continued to rise. Currently, the incidence of fatty liver increased over 5 times five years ago, Beijing, Nanjing and Shanghai, healthy population census found that fatty liver prevalence rate of 10%-15%, the incidence of fatty liver in Nanjing in 1998 was 8.99%, up to 12.33% in 2002. PURPOSE:As pathogenesis of fatty liver is the liver and spleen deficiency, phlegm and blood-stasis, the major treatment methods is nutriting liver and spleen, dispersing phlegm Tongmai, we established decotion of shouwuyujinxiaozhi to treat fatty liver disease, and explore effective methods of Chinese medicine treatment of fatty liver and drugs, verifying the spleen and liver deficiency, phlegm and blood-stasis pathogenesis, exploring new and effective means to lay the foundation for the treatment of fatty liver.METHODS:The subjects diagnosed with fatty liver, from May 2008-2,009 12 Department of Gastroenterology Hospital in Jiangsu Province,90 patients were randomly divided into the treatment group 45 cases, the control group of 45 patients. Decoction of Chinese medicine treatment group taking daily, thick fried as 200ml,2 times orally. Prescription form: Atractylodes 10g, rhubarb system 8g, Radix 15g, White Mustard Seed 8g, hawthorn 15g, Alisma 10g, turmeric 10g, SSB 20g. Control group:simvastatin (Shu lipid-lowering),10mg/d, were treated for 3 months. Diet while the treatment groups, adjusting the diet, eat more vegetables, fruit, low fat, low sugar and alcohol, physical activity, weight control. Abnormal liver function, appropriate rest. Observe changes in symptoms and signs, blood lipids, liver function, B ultrasound and safety indicators.Results:Radix Xiaozhi soup turmeric to improve clinical symptoms in patients with fatty liver effect is remarkable, after all patients after a course of clinical symptoms were:one in reducing fatigue, nausea or pain over You Xie, abdominal distension, nausea, Pollution on addiction block etc., Shouwu Turmeric Cellulite soup improved significantly higher. Both anorexia side effects in improving significantly the effective rate was 100%. Xiao Zhi Tang Shou Wu Yujin clinical total effective rate was 86.7%, better than simvastatin for 60.0%(P<0.05). The role of signs:the elimination of signs, in addition to a small number of patients with severe fatty liver can still reach the liver ribs, the mild and moderate fatty liver patients had liver returned to normal size. Xiao Zhi Tang Shou Wu Yujin significant role in reducing body weight, suggesting that this compound in promoting the use of fat metabolism and reduce fat deposition in the viscera, there is a role, thus alleviating the occurrence and development of fatty liver. Before treatment, lipid treatment group and control group was significantly higher in the treatment group compared with the control group, significant differences (P>0.5). After treatment, decreased significantly in the treatment group compared before and after their TC (P <0.01) TG (P<0,01), etc. and the control group (P<0.05). So decotion of Shouwu Turmeric Cellulite soup can effectively Regulation of blood lipids, improving lipid metabolism. The decotion of Shouwu Turmeric reached a purpose clear lipid sediment in the liver, the liver ultrasound images has been very significant improvements with mild fatty liver, resuming its normal effect on moderate and severe fatty liver cannot fully return to normal, according to previous clinical experience, patients taking extended time, medication 3 months to six months, might be cured. No adverse effects are found after long-term use.CONCLUSION:Pathogenesis of fatty liver mainly lies in the liver and spleen deficiency, phlegm and bloodstasis, with the principle nourishing liver and spleen, dispersing phlegm and Tongmai, the decotion of Shouwu Turmeric xiaozhi was established, and the effect of this treatment with fatty liver was satisfied.