| Stomach cancer (gastric cancer) was a common threat to human life and health of malignant tumor, how to reduce or prevent recurrence and metastasis, advanced gastric cancer patients to improve quality of life and prolong survival, combined treatment of gastric cancer is the most concern.By combing Chinese medicine in ancient literature, one can see, the Chinese has long been documented for the treatment of gastric cancer. And differentiation in the Etiology, Pathogenesis and treatment were recorded. Professor Liu Chenlin Integrative Medicine is a well-known experts in cancer prevention, particularly in the treatment for gastric cancer mainly has its unique digestive system. This topic summarizes the instructors full control gastric academic thought:(1) Integrative Medicine is the treatment of gastrointestinal tumors in major academic model; (2) the principle of individuation is the only way for treating gastrointestinal tumors; (3) with survival palliative treatment of advanced gastrointestinal cancer is a feasible path; (4) improve the therapeutic regimen is an important part. Clinical practice shows that a large number of long-standing anti-cancer Spleen Yin method of Chinese medicine have improved the quality of life in patients with gastric cancer, inhibit cancer metastasis and recurrence, stability, and shrink tumors and prolong survival role.Clinical ResearchPurposeSpleen Yin method of cancer, the effect of the treatment of advanced gastric cancer, and whether the progress can improve the quality of life of cancer patients.MethodSelect January 2006-2,0081 month, Jiangsu Province Tumor Hospital inpatient admitted to and followed up 138 cases of gastric cancer patients after surgery. In addition toconventional nutritional support treatment to all cancer patients were treated with spleen Yin decoction Prescription Act, according to TCM addition and subtraction. Day 1, decoction, oral to 400ml,2 times daily morning and evening 9:00 service. Continuous take 3-6 months. And using the European Organization for Research and Treatment of Cancer Quality of Life developed the Chinese version V3.0 (European Organization for Research and Treatment, EORTC QLQ-C3O V3.0 Chinese version); and the American Medical Research Council's health survey research (Medieal outeomes studies short form-36seales Chinese, MOS SF-36) Evaluation of quality of life before and after treatment.ResultSpleen by 3 months of treatment of cancer Yin,90%of the patients quality of life performance in different degrees of increased levels.ConclusionSpleen Yin method can effectively improve the cancer advanced gastric cancer patients quality of life.Laboratory Animal ResearchPurposeSpleen Yin cancer research cancer treatment method of the theoretical basis for understanding of their protein and gene levels of gastric cancer in the level of the growth, metastasis and recurrence theories.MethodNUGC-4 human gastric cancer cell line was tranfected with red fluorescent protein retroviral vector pLNCX-DsRed-2.Orthotopic gastric tumor model was established by implanting tumor tissue fragments on the gastric of nude mouse.The tumor-bearing mice were randomly grouped into four groups each comprising 8 mice (Group 1, untreated control; Group 2,5-FU positive control; Group 3:high dose of Weianning; Group 4:low dose of Weianning). The treatments were initiated on day 7 after tumor implantation. Tumor size was measured by fluorescence in vivo imaging on day 7,14,21 and 28.The study was terminated and open fluorescence imaging was performed on day 35 to examine primary tumor and metastasis. The primary tumor was excised and weighed at autopsy. Then were used immunohistochemistry and RT-PCR in tumor tissue levels of Fas/Fasl, Bcl-2/Bax in protein expression and gene expression levels.ResultHigh dose Weianning showed significant efficacy on the tumor growth and non-significant inhibitory effect on metastasis of NUGC-4 gastric cancer in orthotopic tumor mouse model without obvious toxicity. The inhibitory effect is dose-dependent. Spleen Yin cancer tumor tissue of nude mice treated in the Fas/Fasl, Bcl-2/Bax protein and mRNA expression levels of up to varying degrees.ConclusionSpleen Yin anticancer therapy can improve the Fas/Fasl, Bcl-2/Bax expression and inhibit tumor progression and metastasis.Conclusion and outlookIn this experiment I found that spleen Yin Treatment of advanced gastric cancer good effect:you can significantly improve the patients quality of life; the same time we also found that animal studies can Spleen Yin decoction cancer increase in tumor Fas/Fasl, Bcl-2/Bax levels in protein and gene expression levels, provide a theoretical basis for clinical use.
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