| Objective Male infertility affects human health and well-being of families, genitourinary tract Ureaplasma urealyticum (UU) infection is closely related to male fertility. At present, medical researcher and clinical workers have made useful exploration in Chinese medicine for the treatment of UU infection in infertility, and achieved some results, but its mechanism needs further study. Previous studies have shown that, Zhibai Dihuang pill(ZBDHP) can effectively inhibit the growth of UU; can be reduced the apoptosis of spermatogenic cells; anti infection and immune regulation function. In this study, based on previous studies, through the observation of clinical curative effect of ZBDHP treatment of UU infection in infertility patients, to observe the functional integrity of sperm membrane and uPA changes in the situation before and after treatment, To explore the effect of ZBDHP on uPA and the Function of Sperm Membrane in Male Infertility patients with UU-infection.Methods30cases of male infertility patients with UU infection were randomly divided into2groups:treatment group of72cases (Group A) were given ZBDHP while control group of58cases (Group B) were given antibiotics.50infertility patients without UU infection were blank group to be compared with the UU infection groups. After3months of treatment, semen parameters, uPA and the functional integrity of sperm membrane were analyzed to observe the clinical efficacy.Results1. The sperm motility, viability and percentage of normal sperm morphology in UU infection groups were lower than those in non-UU infection group (P<0.05), but the sperm density had no significant differences between groups (P>0.05). After treatment, there were statistically significant differences between Group A and B in sperm viability, vigor and percentage normal morphology difference (P<0.05); the sperm density of Group A was higher than that of Group B but without statistical differences between2groups (P>0.05).2. The total rate of sperm expansion and G expansion rate in UU infection groups were lower than those of non-UU infection group; the differences were statistically significant (P<0.05). After treatment, the total expansion rate and G sperm expansion rate of Groups A and B were increased; the total rate of expansion and G expansion rate of sperm in Group A were better than in Group B with statistical difference (P<0.01).3. The acrosin activity and sperm membrane uPA content in UU infection groups were lower than those in non-UU infection group; the differences were statistically significant (P<0.05). The sperm acrosin activity and uPA content of Groups A and B were significantly improved after treatment; there was statistically significant difference between2groups (P<0.01).4. In ZBDHP group the cure rate was25.71%and the total efficiency was88.57%; in control group the cure rate was13.79%, and the total effective rate was67.25%; the differences between2groups were statistically significant (P<0.01).Conclusion UU infection can damage sperm membrane integrity, leading to decrease of sperm membrane uPA content; Zhibai Dihuang pill can eliminated UU, protect the function of sperm membrane and make the sperm membrane uPA content return to normal, so ZBDHP is effective in the treating UU infection in infertility.. |
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