Add And Subtract Chai Shao Six Jun Decoction To Change Shape Reflux Esophagitis Clinical Studies

Objectiveto observe the side Chai Shao Six Jun decoction treatment of reflux esophagitis, while detecting Chai Shao Six Jun decoction to treat the disease of esophageal mucosal inflammation after improvement, to provide clinical traditional Chinese medicine in treatment of reflux esophagitis curative effect of evidence.Methodsby reference to two aspects of traditional Chinese medicine, western medicine diagnostic criteria, will conform to change the type of reflux esophagitis outpatients, a total of60cases. Randomly divided into control group and treatment group, The control group,30cases of oral diazepam tora azole enteric capsules40mg,1times a day, half an hour before breakfast. Treatment group,30cases of oral Chai Shao Six Jun decoction:radix bupleuri, radix paeoniae alba10g,10g dangshen15g,15g atractylodes poria cocos15g, licorice, corrugated30g,6g fish ancient15g,10g magnolia bark. Add and subtract:move bowels viscous painfully uncomfortable and magnolia officinalis, betelnut; Much less when the stool, and discharge breakdown are liver depression and qi stagnation, increase abdominal skin, orange, cortex albiziae, etc.; Constipation, unable to defecate, reuse of atractylodes50g, add orange, c.; Sore throat was diluted with Holly root, parent coals; Sore throat is dry with butterflies, cultured; Bloody and white and, sophora japonica; Heart strong, the tip of the tongue is red and gardenia;Insomniacs and keel, oysters, khan bulls and floating wheat; Blood stasis and salvia miltiorrhiza, rhizoma sparganii, radix curcumae. Decoction methods:our hospital medicine tisanes chamber unified generation of frying,200ml x2bags, each pay medicine early,2hours after lunch, warm clothing. For4weeks as a course, take2course of treatment. Before and after treatment in patients with symptoms score, at the same time do gastroscope, esophageal mucosa biopsy were analyzed. Through integral, endoscopy results and mucosal biopsy results are integral, evaluation of wood Que tonga minus six king party in treatment of reflux esophagitis, recent clinical curative effect, and in the process of test were observed before and after medication general physical examination project, blood, urine, stool routine, liver, kidney, blood electrocardiogram (ecg), in order to understand the drug adverse reactions.Results1. combined with clinical curative effect of scoring, the results of gastroscope, esophageal mucosal biopsy to evaluate the results, the control group and treatment group, compared two groups of clinical curative effect, treatment group cure rate38.76%, total effective rate was85.89%; The control group cure rate was30.41%, total effective rate76.32%, efficient and cure rate between two groups has no statistical significance (P>0.05).2. In the aspect of clinical main symptoms improved, two groups of no significantly difference (P>0.05), but the hiccups, gas frequently, anxiety, depression treatment group was better than that in control group, there is a significant difference (P<0.05).3. Endoscopic esophageal mucosal inflammation, relieve the situation is, two groups of endoscopic esophageal mucosal inflammation changes after treatment showed that the treatment group total effective rate was85.43%, control group total effective rate69.21%and the control group respectively, the comparison between the two groups have significant difference (P<0.05).4. The pathologic examination of esophagus mucous membrane inflammation changes according to the results the two groups after treatment had significant difference (P<0.05).ConclusionChai Shao Six Jun decoction in treatment of change the type of reflux esophagitis than western medicine panxi tora azole enteric capsules treatment effect is no statistical significance, but the total cure rate is high, and can significantly improve the clinical symptoms, endoscopic esophagus mucous membrane inflammation is also significantly reduced. For reflux esophagitis curative effect is to use his own early. Inference according to the results of the treatment the curative effect of his own in treatment of reflux esophagitis may lie in the following aspects:with enhanced gastrointestinal dynamics, speed up the emptying of the duodenum, inhibition of gastric juice and bile secretion, can inhibit inflammation, enhance the effect of esophageal mucosal repair, etc. Wood Que six gentleman soup has no obvious side effects, safety, can be applied to the clinical further promotion.