Inhibition Of Quercetin On Rabbit Ears Oral Hypertrophic Scars

Background:In vitro observations suggested that quercetin had a potential for the treatment of excessive scars. There has been no study about the effect of oral quercetin on hypertrophic scarring.Objective:to examine the effect of oral quercetin on hypertrophic scarring in the rabbit ear model.Methods:Standardized wounds, four per ear, were created on the ears of nine New Zealand White rabbits, for a total of72scars. Three of the rabbits received daily ingestion of quercetin or asiaticoside, respectively. And the other three received no intervention. After4weeks, the resulting ear scars were harvested. Histological slides were prepared from the thickest cross-sections of the scars, and hypertrophic index was calculated by comparing the area of the scar to the baseline value of unwounded skin.Results:Among the rabbits treated with asiaticoside, the mean hypertrophic index was1.55±0.03, compared with1.67±0.02in the control group (p=0.003), representing a17.9%reduction in hypertrophic area. Among the rabbits treated with quercetin, the mean hypertrophic index was1.59±0.03, representing a11.9%reduction in hypertrophic area, but there’s no significant reduction in scar hypertrophy compared with the control group (p=0.053).Conclusions:Orally administered asiaticoside significantly reduces the severity of hypertrophic scarring in the rabbit ear model. The inhibitory effect of oral quercetin on hypertrophic scarring still needs further investigation.