Compare The Effects Of Two Different Radiotherapy Methods-the I¹²⁵ Seeds Implantation And Afterloading Radiotherapy-in Cervical Cancers On Mouse Model

Objective:To compare the curative effects of two different radiotherapy methods, the Iodine-125seeds implantation and Afterloading radiotherapy,in cervical cancer on mouse model.Methods:Two kinds of human uterine cervical cancer cell lines (Hela and C33A) were injected into100BALB/C nude mice. In the next46days,76of them were randomly selected into three groups, the Iodine-125seeds implanted group, the Afterloading group and the control group. After3months observation, most of them were killed, to compare the curative effect and side effects of these two radiotherapy methods.Results:In the Hela tumors model, Iodine-125seeds implantation showed an excellent tumor control effect, even a little better than the Afterloading radiotherapy. Compared with the Afterloading radiotherapy, the Iodine-125seeds implantation had a smaller skin radiation damage and weight loss. In the C33A tumor models, these two radiotherapy methods didn’t have such satisfied curative effects.Conclusion:The Iodine-125seeds implantation has the same curative effect as the Afterloading radiotherapy method, but has a smaller side effect. It may have a bright future in the clinical treatment of uterine cervical cancer.