Recurrent Oral Ulcers Syndrome Characteristics And Herbal Prescription Evolution

Objective:To study common syndrome types and drug-using characteristics of Recurrent oral ulcer(ROU) by the method of philology and statistics, preliminarily reveal prescription compatibility regularity,and provide literature basis for Chinese medicine clinical research and new drug research and development.Methods:(1)Literature research method:Choosing China Biology Medicine disc (CBMdisc), VIP journal full-text database, Tsinghua tongfang periodical database, searching clinical literature about TCM treating ROU from1989to2011. We established data sheet according to microsoft access,and it has been typed-in analysis of Traditional Chinese Medical prescription software which was united developed by Chengdu university of TCM and Southwest Jiaotong University.(2)Statistical analysis method:frequency analysis.relational analysis and clustering analysis were applied to statistical analyze syndrome types,compound prescription herb sort.core medicine.couple drug, commonly used formula and indication in both internal treatment and external therapy prescription.Results:(1)Syndrome type characteristics:In482syndrome types of internal treatment prescription, excess syndrome accounts for41.08percent, deficiency syndrome accounts for32.37percent,mix of deficiency and excess syndrome which takes larger proportion,accounts for24.07percent.The top five syndrome types by frequency are Yin Huo-wang, heart and spleen accumulated heat, damp, spleen, Qi and Yin deficiency, toxic heat flaming. In83syndrome types of external treatment prescription, excess syndrome accounts for61.47percent, deficiency syndrome accounts for15.66percent,mix of deficiency and excess syndrome accounts for14.46percent.The top five syndrome types by frequency are Toxic heat flaming; stasis heat within the depression; spleen hot and humid; Yin deficiency of toxic heat flaming; Yin Huowang.(2)Medication charateristics:The top ten internal treatment prescription herb sort successively are heat-clearing medicine,complement deficiency medicine, dampness-clearing drugs, diaphoretic drugs, interior-warming drugs, activating blood and dissolving stasis medicine,reducing phlegm-relieving cough and asthma medicine, astringent medicine, aromatic damp-resolving drugs and qi-regulating drugs.The top ten core herbs by usage successively are radix rehmanniae recen, berberine, poria, ophiopogon, tree peony bark, skullcap, angelica, astragalus, treats, Scrophulariaceae.Couple drugs in common use are rehmanniae, bamboo, alisma, yams,ect.The top seven external treatment prescription herb sort successively are heat-clearing medicine, diaphoretic drugs, awaking drugs, complement deficiency medicine,other drugs,drawing pus-promoting tissue regeneration drugs and astringent medicine. The top ten core herbs by usage successively are borneol, indigo, treats, berberine, gall,, borax, mint, cutch, asarum,Alum.Couple drugs in common use are borneol, indigo, borneol, treats,ect.(3)Prescription characteristics:The top four internal treatment prescriptions are Daochi Powder,by liquid soup,Yu Nvjian, Qingwei Powder.(4)Common use herbs based on syndrome:In internal treatment prescription, golden cypress,anemarrhena,moutan rehmanniae, scrophulariaceae are often used in type of yin deficiency-fire excess; rehmannia root, akebia, berberine, bamboo leaves, gardenia are often used in type of brimming heat of heart and spleen; atractylodes, rehmannia, ophiopogon, berberine often used in type of deficiency of both qi and yin: baicalin, berberine. gardenia often used in type of dampness-heat retention; Toxic heat flaming compatibility berberine, baicalin, Treats, gardenia, honeysuckle, codonopsis, Drugs on the mutual compatibility made by the commonly used drugs.Conclusions:The syndrome characteristics of ROU include two sides:the deficiency and the excess,while syndrome of intermingled deficiency and excess is the relatively common one.Yin deficiency,deficiency of both qi and yin and yang deficiency are commonly seen in the deficient root syndromes of ROU,while fire-heat and dampness-heat often constitue the excessive superficial syndrome which presents symptom of brimming heat of heart and spleen,up-flaming fire,or dampness-heat retention, caused by dampness-heat steeping myolemma of mouth and tongue. The deficient root presents symptom of both qi and yin deficiency,or yin-fluid insufficiency which gives rise to up-flaming fire,or yang deficiency of both kidney and spleen, deficient yang with upper manifestation,leading to myolemma malnutrition in mouth and tongue,then myolemma decays into ROU,ultimately caused the meridian barrier, blood stagnation, burning rot sarcolemma disease.Long time desease causes deficiency-excess mixing and the deficient root-excessive superficial syndrome.The internal treatment prescription can remove pathogenesis by the method of heat-clearing,dampness-resolving,cold-dissipating and stasis-dispersing,and also consolidate vital healthy qi by supplementing qi,nourishing yin and warming yang.The external theraphy prescription can string dampness and furuncle, relieve swelling-pain and drawing pus-rot according to the local disease differentiation on one hand,also can remove pathogenesis and regulate the viscera based on entire body syndrome differentiation by the method of heat-clearing,blood-activating, qi-supplementing and dampness-resolving,which reflects the differentiation theraphy model of disease differentiation combined with syndrome differentiation.