Study On The Composition Of The Banxiaxiexin Decoction And Its Derived Formulas Based On Regularity Of "OD-IM-RD"

Banxiaxiexin Decoction and its analogous(Gancaoxiexin Decoction,Shengjiangxiexin Decoction, as follows called 3 Xiexin Decoctions) is one of 12 kinds of analogous in "Shanghanlun",which is the representative formula of Pi Syndrome (glomus and fullness) treated by Zhang Zhongjing. Pi of 3 Xiexin Decoctions Syndrome, the pathogenesis is same. Because of the weakness of spleen and stomach, inward fall of pathogenic heat, the pathogenic cold and pathogenic heat tied in center mutually, disharmony of ascending and descending between the spleen and the stomach, obstruction of flow of QI, caused by mistreatment or normal treatment.It has the certain similarity and the difference to adding and subtracting of 3 Xiexin Decoctions according to difference syndrome, and it is a fine template of difference research of analogous. Moreover, compatibility of principal, adjuvant, auxiliary and courier herbs in 3 Xiexin Decoctions is complete, and it may fully embody the guide of principal, adjuvant, auxiliary and conduction ingredirnts to formulate of complex prescription. 3 Xiexin Decoctions implicature the method of opening with acrid agents and draining with bitter agents initiated by Zhang Zhongjing. It reflects the guide of drug property theory to formulate. Therefore, study on the Composition of the Formula Banxiaxiexin Decoction and Its Derived Formulas can reveal the Composition rule of principal, adjuvant, auxiliary and courier herbs, drug property theory, analogous discrepancy. The article is divided into three parts. The first part refers to research methods on complex prescription and its derived formulas. proposed research Regularity in this part, "Optional Dismantlement—Intelligence Modeling—Discovering Knowledge of Analogous Preparations" ("OD-IM-RD"). The second part is the model establishment of nonlinear mapping formula of ingredients, dosage and pharmacodynamics. This part aims at type and feature of optional prescription dismantlement data. For realizes the goal of computer simulating experiment, the work give consideration to complex non-linear relations among ingredients in complex prescription, tested and verified the complex mutual relationship among the ingredients in the prescriptions according to the nonlinear mapping formula of ingredients, dosage and pharmacodynamics produced by BP neural network. Compared with former modeling of multiple linear regression, confirm the efficiency of the constructed model according to evaluation competent of model prediction. The third part for model application, this part investigate Composition of the Formula Banxiaxiexin Decoction and Its Derived Formulas from the relations of ingredient, dosage and potency of mono-drug, principal, adjuvant, auxiliary and courier herbs, drug property theory, and analogous discrepancy. 1 Proposed the new research Regularity The work established and applies Regularity of "OD-IM-RD" to Study the Composition of the Formula Banxiaxiexin Decoction and Its Derived Formulas, realized the research goal of ingredients in a prescription, dosage and Composition of complex prescription. The work studied prescription dismantlement according to the uniform design layout, reduces the experimental times from 81 groups of orthogonal design to 24 groups. At the same time experiment result still could reflect the main characteristic of the experimental system. There is not appropriate model of complex non-linear relations of ingredients, dosage and pharmacodynamics. Tested and verified the complex mutual relationship among the ingredients in the prescriptions according to the nonlinear mapping formula produced by BP neural network. Because it has the capability of non-linearity, auto organization, auto learning, the nerve network can predict all different experimental data of ingredients, dosage and pharmacodynamics from knowledge which obtained data from 24 groups test. The model realizes the study of 8 groups to 24 groups ,and even n group. Introduced thinking model of holism and system theory of Chinese medicine, the work explained the Composition...