A Clinical Study On The Treatment Of The Symptoms Of Qi Deficiency And Stagnant Heat Of Refractory Hepatitis C With The Method Of Eliminating Blood Stasis And Toxin In Combination Of Interferon And Qi Deficiency And Stagnant Heat

Chronic viral hepatitis C is the chronic inflammation and necrosis of liver caused by continuous hepatitis C virus(HCV)infection;it is one of the important reasons for inducing cirrhosis and liver cancer.The treatment of chronic viral hepatitis C mostly adopts the standard treatment plan based on the combination of ribavirin and peginterferon.Yet,there are still a certain number of patients who cannot get sustained viral response after receiving the treatment according to the standard plan;these patients fall into the group of refractory hepatitis C(RHC).In recent years,the mechanism research and dialectical treatment of RHC by Traditional Chinese Medicine(TCM)have demonstrated the advantages to some extent.Objective:To discuss the clinical treatment effects for RHC(Qi deficiency and stagnant heat)via the combination of xijiaodihuang decoction,minus interferon and antiviral drugs,based on the supervisor’ s clinical experience summary and guided by the method of supplementing Qi and Yin and eliminating blood stasis and toxin;to provide a basis for the treatment of RHC by TCM by way of evaluating the treatment effects of TCM-related symptoms,liver functions,virus indexes,safety,etc.Methods:In line with random,control and parallel principles,80 RHC(Qi deficiency and stagnant heat)patients were selected and finally divided into two groups,with 38 patients in treatment group and 37 patients in control group,after eradicating the drop-out patients.The treatment group was medicated with xijiaodihuang decoction,in combination with Western medicine(hypodermic injection of peginterferon and oral administration of ribavirin);the control group was medicated with only Western medicine(hypodermic injection of peginterferon and oral administration of ribavirin).With 48 weeks as a treatment cycle,the treatment effects of symptoms,and the per-item symptoms and signs before and after the treatment were observed;the laboratory indexes such as liver functions(ALT,AST,GGT,etc),chronic hepatitis C virus(HCV-RNA)content,and myelosuppression indexes(WBC,PLT)were tested;the treatment effects and safety were evaluated.Results:1.In the treatment group and the control group in the comprehensive curative effect,the effect rate was not statistically significant(P>0.05),the effective rate and the total effective rate were statistically significant(P<0.05).Total symptom scores,total effective rate and total effective rate were statistically different(P<0.05).After treatment,the liver pain,fatigue,anorexia,abdominal distension,liver,skin armour fault complexion,the treatment group than the control group(P<0.05).2.The treatment group ALT and AST(P<0.05)were significantly better than the control group.3.The two groups of virus quantitative value comparison(P<0.05),there is significant difference,the treatment group antiviral effect is better than the control group.Conclusion:The treatment of RHC(Qi deficiency and stagnant heat)with xijiaodihuang decoction,in combination with peginterferon and antiviral drugs under the guidance of the methods of supplementing Qi and Yin and eliminating blood stasis and toxin can achieve excellent clinical effect,and it has great advantages in alleviating liver pain,fatigue,anorexia,abdominal distension,scaly dry skin,dim complexion,dysphoria in chest,palms and soles,etc.This treatment can improve liver functions,reduce HCV content and it has the advantages of minimal side effect,reliable safety and desirable treatment effect.