Study Of Magnesium-based Antibacterial Agents Property And Preparation Of Antibacterial Fabrics

Microbiological pollution is harmful to environment and health,and the emergence of antibacterial agents can solve such problems.Inorganic magnesium-based antibacterial agents can overcome the disadvantages of natural antibacterial agents and organic antibacterial agents.Magnesium-based antibacterial agents have become the hotspot due to broad-spectrum antibacterial property,non-toxicity,and stability.Especially,magnesium-based antibacterial agents are effective even without light irradiation and not easy to result in drug resistance.1.Escherichia coli(E.coli)was used as a microbial model to research the antibacterial property,the oxidative stress response and metabolism(energy metabolism,glucose metabolism and tricarboxylic acid cycle)disorder induced by nano-Mg(OH)2 were analyzed at cellular,enzymatic and genetic level.These physiological changes led to the death of the microbial model.2.In order to prepare magnesium-based antibacterial PET fabrics,the composited brucites powders were coated on PET fabrics by coating method using waterborne polyurethane.The grinding and compounding process didn't change the chemical bonds and the crystal structure of brucites,but to achieve mechanical deformation and mutual doping,and maintained the original antibacterial property of brucites.The coating process achieved a physical adsorption of bracites and waterborne polyurethane on the PET fabrics.The magnesium-based antibacterial PET fabrics had excellent mechanical property,broad-spectrum antibacterial property and good laundering durability.3.The modifier(titanate coupling agents and stearic acid)improved the lipophilicity of nano-Mg(OH)2,which achieved the preparation of permanent magnesium-based antibacterial PET fabrics using hydrophilic nano-Mg(OH)2 and hydrophobic PET by melting-and-mixing technology.The modifier and masterbatch technology overcame a problem that nano-Mg(OH)2 is unevenly dispersed and easily agglomerated in PET.The antibacterial PET fabrics simultaneously had excellent broad-spectrum antibacterial property,mechanical property and laundering durability.4.In order to achieve safe and extensive use of magnesium-based antibacterial agents,the biosecurity needs to be evaluated.The acute oral toxicity test indicated that the safe-use dose of nano-Mg(OH)2 was more than 10000 mg/kg,belonging to the actual non-toxic level.This dose had no pathological damage to the vital organs of body,and the body's metabolism was normal.The cytotoxicity experiment of human embryonic lung fibroblasts(HELF)and rat adrenergic neural tumour phaeochromocytoma(PC-12)showed that nano-Mg(OH)2 had no toxic effect on the respiratory system and the brain nervous system.Additionally,the blood physiological markers showed that Mg(OH)2 had no effect on the blood system.The above experiments indicated that the inorganic magnesium-based antibacterial agents have excellent biosecurity.