A Study Of The Formula Syndrome And Application Rule Of Minor Decoction Of Bupleurum

Objective:Minor Decoction Of Bupleurum is a classic formula recorded in the book Shang Han Lun written by Zhang Zhong Jing.This formula is the representative formula of the Shaoyang disease.It is also the basic formula for treating the Shaoyang disease.Minor Decoction Of Bupleurum has a wide coverage of application,the formula syndromes are various and complicated.The posterity has many treatises about this formula,they have various advocates and not standardized.Besides that,in the book Shang Han Lun also recorded the various modification rules of the formula.Nowadays,the technology is advance,the research study and new explore of application of the formula also be done and has a breakthrough.The application of the formula also widely extended.Therefore,this research aims to make a conclusion about the application and modification rule of this formula by analysing the Chinese medicine literature.Through collecting the data systematically,we aim to conclude the rule of application and modification of this formula to explore a new ciinical application concept,rule out the method of modification of the formula.Methods:The design of the research is to collect the cases of applying Minor Decoction Of Bupleurum from the publication published in the past 11 years.The data are collected through internet.The data collected based on certain standard.The data include the date,the duration of the disease,the treatment duration,the herb components of the original formula,the additional herbs,the dosage,etc.The data collected for example the formula syndrome,the symptom and dosage will be analysed using various statistical method.The statistical methods include the frequency,association rule and golden segmentation rule.Through these statistical analysis,we aim to study the etiology,patho mechanism,modification rule and dosage of the formula.Results:Base on the statistical analysis,the diagnosis of cough and cold have the highest frequency.If categorized the diagnosis based on Internal medicine categorized method,the lung disease has the highest frequency among the diagnosis,followed by digestive disease,gynaecology and liver disease.The lowest frequency of the diagnosis is the andrology.The main symptoms are low appetite and bitter taste in the mouth.The main tongue diagnosis is red tongue with white or yellow tongue coating.The wiry pulse(include the combined pulse contain wiry pulse)is the main pulse diagnosis.Among the 505 cases,100 cases presented only one symptom out of Shaoyang seven main symptoms.The highest frequency of the symptoms presented is the low appetite,the lowest frequency of the symptom presented is the dizziness.The duration of the syndrome is most likely within 2 weeks or more than one year,while the treatment duration is mainly within 2 weeks,cured less than 15 dosages.The core herb components include Bupleurum,Scutellaria,Pinellia,licorice,ginseng,and main herb components are ginger and jujube.The high frequency additional herbs include the medicine for clearing heat,tonic,medicine to release exterior syndrome,diuresis and medicine to regulate qi.Medicine to clear toxic,expel parasite and induce emesis have the lowest frequency among the herbs used.The most frequent modification of the formula is the original formula without ginseng,ginger and jujube.As for the gender,the formula syndrome more frequently presented in woman.The use of the decoction is mainly for the patient between 30 to 50 years old.The syndrome mainly found in the spring.From the analysis based on the association rule,we found that the confidence between two symptoms which are more than 38.2 include bitter taste in the mouth-dryness in the throat,bitter taste in the mouth-fullness in the chest,bitter taste in the mouth-yellow tongue coating,bitter taste in the mouth-light tongue,low appetite-yellow tongue coating,low appetite-bitter taste in the mouth,low appetite-dryness in the throat,low appetite-fullness in the chest,dryness in the throat-fullness in the chest,dryness in the throat-yellow tongue coating,dryness in the throat-light tongue,restlessness-disturbed sleep,fullness in the chest-white tongue coating,fullness in the chest-light tongue.The highest association rate of the symptom is the bitter taste in the mouth-dryness in the throat.As for the association between the herbs,the confidence between two herbs which are more than 38.2 include scutellaria-pinellia,scutellaria-licorice,scutellaria-ginseng,scutellaria-jujube,scutellaria-ginger,pinellia-ginseng,pinellia-licorice,pinellia-jujube,pinellia-genger,licorice-ginseng,licorice-jujube,licorice-ginger,ginseng-jujube,ginseng-ginger,jujube-ginger,poria-atractylodes,angelica-chuanxiong,forsythia-honeysuckle and red peony-cortex moutan.The confidence between herb and sympthom which are more than 38.2 include scutellaria-bitter taste in the mouth,pinellia-bitter taste in the mouth,licorice-low appetite,licorice-bitter taste in the mouth,ginseng-low appetite,ginseng-bitter taste in the mouth,ginger-low appetite,ginger-bitter taste in the mouth,ginger-fullness in the chest,jujube-low appetite,jujube-bitter taste in the mouth,jujube-bitter taste in the mouth,jujube-fullness in the chest and apricot seed-cough.Highest frequency of the combination of original formula with additional herbs are various.Poria,white peony root,atractylodes,dried tangerine peel,angelica,chuanxiong,citrus aurantium,cassia twig,magnolia,saposhnikoviae,alisma,salvia,cyperus rotundus and gypsum more often combine with original formula,while campanulaceae,apricot seed,rhubarb,red peony,gardenia,cortex moutan,honeysuckle and coix seed more often combine with original formula without ginseng,jujube and ginger.The different combinations of herbs associate with different symptoms.The original formula combination or original formula combine with additional herbs mainly associate with the symptoms bitter taste in the mouth,low appetite,dryness in the throat and frequent vomit.The original formula without ginseng,jujube and ginger mainly associate with the symptoms of frequent vomit,fullness in the chest,irritation,dryness in the throat,disturbed sleep,low appetite and bitter taste in the mouth.The original formula adds poria mainly associate with the symptoms of frequent vomit,fullness in the mouth,irritation,dryness in the throat,disturbed sleep,low appetite and bitter taste in the mouth.The original formula adds white poney mainly associate with the symptoms of irritation,fullness in the chest,bitter taste in the mouth and low appetite.The original formula adds atractylodes mainly associate with the symptoms of bitter taste in the mouth,dizziness,dryness in the throat,disturbed sleep,frequent vomit,low appetite and fullness in the chest.The original formula adds angelica mainly associate with the symptoms of irritation,abdominal fullness and pain and fullness in the chest.The original formula without ginger,ginseng and jujube mainly associate with the symptoms of dryness in the throat,cough,fullness in the chest and low appetite.The original formula without ginger,ginseng and jujube adds campanulaceae mainly associate with the symptoms of dryness in the throat,cough,fullness in the chest and low appetite.The original formula without ginger,ginseng and jujube adds coix seed mainly associate with the symptoms of pain and fever.The original formula adds poria and atractylodes mainly associate with the symptoms of frequent vomit,dryness in the throat,dizziness,bitter taste in the mouth,disturbed sleep,low appetite and fullness in the chest.The original formula adds chuanxiong and angelica mainly associate with the symptom of pain and fullness in abdomen,disturbed sleep,fullness in the chest,irritation and pain.Conclusion:Through collecting the cases published by the physicians from different area of China and analyse the combination of herbs can effectively discover the characteristic and application rule of Minor Decoction Of Bupleurum formula syndrome.After the statistical analysis,we conclude:1.Female is more frequently presented with Minor Decoction Of Bupleurum formula syndrome.This syndrome more frequently found in spring,in the age group between 30-50years old.2.The duration of Minor Decoction Of Bupleurum formula syndrome most likely last for 2 weeks or more than 1 year.The treatment duration is most likely less than 2 week,cured less than 15 dosage.3.The application is mainly for treating cough,mainly for lung system disease,and for lung disease,male is more frequently presented with Minor Decoction Of Bupleurum syndrome as compare with female.4.The main symptoms of Minor Decoction Of Bupleurum formula syndrome include bitter taste in the mouth,low appetite,red tongue,yellow or white tongue coating and wiry pulse(include the combined pulse which contain wiry pulse).5.For the discussion of "only see one symptom",statistical analysis find that all seven main symptoms of Shao Yang are included.The low appetite has the highest frequency among the symptoms presented,and dizziness has the lowest frequency among the symptoms presented.6.The additional herbs are mainly pertain to medicine to clear heat while medicine to clear toxic,expel parasite and induce emesis are seldom added in the formula.7.There are association among the main symptoms,but the support and lift are not high,it shows that there are relationships among the symptoms but with certain level of independency.There are association among the herbs,but the lift is not high,it shows that modification of the formula is flexible.8,When analysing the association between herbs and symptoms,we found that some of the combination are high confidence and support which worth to have further study about the association between those herbs and symptoms.The various combination of original formula components with additional herbs associate with different symptoms,it shows the modification of Minor Decoction Of Bupleurum can be applied widely and flexibly.