Study On The Evaluation And Improvement Of The Key Technology Of The New Type Of Copper Containing Antibacterial Titanium Alloy In Department Of Orthopedics

Background and Objective:Internal plant related infection is the most common and troublesome complication in the Department of orthopedics.Once the infection is out of control,it will result in the failure of the operation,systemic infection,amputation and even death.Good treatment effect are reported for intravenous administration of antibiotics and implants contained antibiotics,but antibiotic resistance can not avoided,we use the antibacterial properties of metal ions,the new titanium alloy containing copper as the research object,to evaluate the animal in vivo antibacterial and safety performance,based on the results from the improved antibacterial metal implant materials in order to find the ideal,the ultimate realization of the clinical transformation completely solve the problem of infection related plants.Methods:?8 beagle dogs were randomly divided into experimental group implanted Ti-6A1-4V-5Cu alloy bone screws,the control group was implanted with Ti-6Al-4V alloy bone screws,simultaneous injection of Staphylococcus aureus infection caused by the liquid,the experimental group in general,hematology,radiological,bacteriological indicators to evaluate the anti infection ability;?The Ti-6Al-4V-5Cu alloy surface micro nano surface modification,antibacterial ability observed in untreated group,micron group and micro-nano composite group in vitro;Injection of different dosage Cu ion on the surface of Ti-6A1-4V alloy with different dosage and surface morphology of the two factors are divided into 4 groups,to observe the anti infection ability and cytotoxicity between groups;?the 18 beagle dogs were randomly divided into the control group of micro-nano Ti-6Al-4V alloy group,micro-nano Ti-6Al-4V-5Cu alloy group and micro-nano Cu-PIII-Ti-6Al-4 Valloy group to observe the anti-infection ability in the experimental group.Results:The observation,imaging,hematology,bacteriological indexes of the experimental group were higher than those of the control group,but there were still a lot of bacteria in the surface of the nail.The micro-nano Ti-6Al-4V-5Cu alloy after treatment of anti-infection properties have improved,but still can not meet the demand of antibacterial surface after Cu ion implantation;?Micro-nano modification,observed in high dose implantation with micro nano morphology of colony count in experimental group significantly lower than that of control group(P<0.05),and the other experiment group.? The number of bacterial colonies in Ti-6AI-4V alloy with micro nano surface morphology was significantly lower than that in the control group and the micro-nano morphology Ti-6A1-4V-5Cu alloy group by injecting high doses of Cu ions on the surface.Conclusion:the whole Ti-6Al-4V-5Cu alloy was used to prevent and control the infection of the nail canal,and the infection rate and infection rate were reduced to a certain extent compared with the control group.After the whole Ti-6A1-4V-5Cu alloy micro-nano surface modified with antibacterial properties to a certain extent improve;after the surface plasma injection of Ti-6A1-4V alloy Cu has obvious antibacterial antibacterial ability,with the dose increasing,anti infection effect is enhanced,compared with the untreated group of micro-nanotopograghy appearance group had obvious ability enhanced Cu ion anti-infection effect;Cu-PIII-Ti-6Al-4V alloy the surface micro-nanotopograghy processing for artificial hip prosthesis,effectively reduce the occurrence of periprosthetic infection.