| Objective:The system reviews the Chinese tradition medicine and the Western medicine the understanding and the treatment which miscarries to the threatened miscarriage and routine, observes teacher the clinical fetus protection experience to summarize the side-long-lived embryo pill comprehensively to add the taste side addition and subtraction treatment spleen kidney two empty embryos to leak, painful fetal movement, the abortion clinical curative effect, as well as around the treatment the endocrine hormone, the immunity immune body, immunity NK cell activeness and Thl/Th2 cell factor change, discusses its fetus protection by the time from the endocrine-immunology angle the action mechanism, for the rich Chinese medicine theory, the discussion Chinese medicine fetus protection mechanism and the clinical research effective Chinese native medicine compound prescription preparation does the foundational clinical research.Simultaneously also is for teacher in the preliminary animal experimentation foundation the clinical research supplement.Methods:The first part Clinical curative effect observationStochastic selection in the Hunan Chinese medicine university second affiliated hospital and the Hunan Province women's and children's dispensary gynecology department outpatient service and in hospital early time threatened miscarriage, the routine miscarriage requests the fetus protection Chinese medicine dialectical empty either the spleen kidney two empty patients and miscarries the patient for the kidney who inevitable or the miscarriage not all requests the clear palace, the normal pregnant woman who the mother and child care branch reception embryo works, the altogether 160 examples, divide into 4 groups:The long-lived embryo pill adds the taste side treatment group 50 examples, guarantees the treatment control group 50 examples, miscarries the control group 30 examples, the eukyesia has not taken the fetus protection medicine control group 30 examples.4 group of patients simultaneously all take orally the Vitamin E:100mg, bid×60 day and the folic acid:0.4mg, Qd×90 day.Around observation treatment curative effect and symptom change and general secure observation.The second part Clinical endocrine internal secretion-immunology researchEmission immunity law (RIA) examines the long-lived embryo pill to add the taste side treatment group example and the fetus protection spirit treatment control group treats blood serum HCG, P,?-EP the change and the eukyesia group comparison.Emission immunity law (RIA) examination circumference blood EMAB (anti-endometrium immune body), AsAb (anti-sperm immune body), ACA (anti-cuorin immune body) change.Uses ELSIA method examination circumference blood NK cell activeness and the blood TNF-?, IFN-?, IL-4, around the IL-10 treatment change.Around third part Fetus protection treatment the antithetical couplet generation of growth growth preliminary observationThrough the telephone, the network or visits made a follow-up visit the part after the fetus protection treatment when the newborn birth the ordinary circumstances including when the young child age, the sex, the childbirth is pregnant when the week, the childbirth way, the birth the Apgar grading, feeds the way, the appetite, the mood, whether there is the congenital disease, whether there is the newborn suffocates the history, the skull internal hemorrhage and other newborn time disease and so on.Time the birth height, the body weight, encircle, data and so on chest measurement, babies and infants' nutrition condition, the skeleton growth, the brain and the skull growth and the chest gallery, chest back muscle, hypodermic fat and lung situations and so on growth..The fourth part Literature researchUses research techniques and so on computer network technology and literature retrieval, epidemiology review to the motherland medicine, the modern medicine as well as the cooperation of Chinese and Western medicine medicine leaks, about the embryo painful fetal movement and the abortion sickness name, the cause of disease pathogenesis, the method of treatment, clinical Fang Yao studies and the current clinical research progress carries on the summary.Indicated the Chinese medicine fetus protection treats has the good effect and the superiority, is worth the clinical research and the promotion.Results:The first part Clinical curative effect observes50 examples to take the long-lived embryo pill to add the taste side addition and subtraction treatment future trouble after the synthesis curative effect determination standard judgment, cures 18 examples, shows results 17 examples, effective 8 examples, invalid 7 examples, total effectiveness 86%; 50 examples take the fetus protection spirit treatment future trouble after the synthesis curative effect determination standard judgment, cures 12 examples, shows results 16 examples, effective 12 examples, invalid 10 examples, total effectiveness 80%; Two groups of effectiveness are high, after but uses the long-lived embryo pill to add the taste side addition and subtraction treatment total effectiveness (86%) to have to be higher than the fetus protection spirit comparison treatment group (80%), but two groups of differences after Radit analysis, P>0.05, difference not remarkable significance.But the long-lived embryo pill adds the taste side treatment group to improve the vagina to bleed, the god tired strength, a night of frequent micturition many, surpasses the fetus protection spirit treatment control group obviously, also has the significance difference (P>0.05).Around two groups treat circumference blood RBC, WBC, HGB, AST, ALT, GGT, CREA, BUN in the normal range, around the comparison difference statistics significance (P>0.05).The second part Clinical endocrine internal secretion-immunologyResearch examination medication four group of blood HCG, the P value, the recording applies drugs latter two medication group blood HCG, the P change, and simultaneously examines the same time eukyesia group HCG, the P value carries on the comparison, miscarries the control group to be opposite obviously in other 3 groups, blood HCG, the P value somewhat low, compares with other 3 groups, the difference has the remarkable significance (P<0.01), other 3 groups compare, have the miscarriage symptom to treat two group of blood HCG, P must be lower than the eukyesia group, but two medication treatment group compares, the difference not remarkable significance (P>0.05), has the commeasurability.After two medication group medication treatment blood HCG, the P rise, around the comparison difference has the remarkable significance (P<0.01); Although after two groups treat the eukyesia group to be low, but difference not remarkable significance (P>0.05). Around two medication groups treat the rise scope with the eukyesia group quite, difference not remarkable significance (P>0.05).Before the examination medication four group of circumference blood value, the recording applies drugs the latter two medication group blood?-EP change, and simultaneously examines the same time eukyesia group?-EP the value to carry on the comparison, miscarries the control group to be opposite in other 3 groups, the blood?-EP value obvious markup, compares with other 3 groups, the difference has the remarkable significance (P<0.01); Other 3 groups of comparisons, had the miscarriage to treat two groups of blood P-EP still to have to be higher than the eukyesia group, but was lower than the miscarriage group, before the medication two treatment group comparison, the difference not remarkable significance (P>0.05), had the commeasurability. After two medication group medication treatment the blood P-EP reduces, around the comparison difference has the remarkable significance (P<0.01); Two groups'treated the eukyesia group to be still high, but difference not remarkable significance (P>0.05).Around but two group of medication treatments blood AsAb, masculine gender rate comparison difference has the statistical significance (P<0.05) blood ACA to add the taste side treatment after the long-lived embryo pill the masculine gender rate drop, after but the fetus protection spirit treatment does not have changes.The miscarriage control group's NK cell activeness eukyesia control group elevates obviously (P<0,01), the long-lived embryo pill adds the taste side treatment group and the fetus protection spirit treatment group also obviously elevates (P<0.01) around, but the long-lived embryo pill adds the taste side treatment group and the fetus protection spirit treatment group treats the eukyesia control group also obviously to elevate (P<0.01), two treatment groups treats compares the NK cell activeness to reduce, the difference has statistics significance (P<0.01). After two treatment groups treated the eukyesia group to compare still are also high, the difference also had statistics significance (P<0.Ol).Has had the miscarriage miscarriage control group TNF-?, IFN-?the content eukyesia group elevates obviously (P<0.01) before, two treatment groups treat compare also obviously elevate (P<0.01), after two treatment groups treat compare the eukyesia group to compare also high, the difference has the statistical significance (P<0.01).On the contrary, has had miscarriage miscarriage control group IL-4, the IL-10 content eukyesia group obvious somewhat low (P<0.01) before, two treatment groups treat obviously compare also somewhat low (P<0.01).The third part Fetus protection treatment the antithetical couplet generation of growth growth preliminary observationRevisit has given birth in 46 example parturient women, the newborn age is biggest 1 full year old, smallest just was born 1 week; In which has not had the premature infant, the full-term galley proof, abnormal and so on, also all has not had the newborn to suffocate the history, the skull internal hemorrhage and so on other situations, the mother is normal.Time the birth body weight, the height, encircle, the chest measurement, the hips with have not adopted the fetus protection treatment the newborn comparison, the difference non-statistics significance (P>0.05).The fourth part Literature researchThrough the literature summary and the analysis, the motherland medicine leaks, regarding the embryo painful fetal movement and the abortion knows comprehensively, "the kidney host reproduction" the pathogenesis in the kidney, abortion Yu of Pishen more responsibility two empty, the long-lived embryo pill clinical peaceful embryo curative effect is mainly prominent, compares the doctor practicing western medicine peaceful embryo security.At present obtained the recognition. Studies the mechanism from the endocrine-immunity aspect which miscarries and treats, is hot spot which at present studies.Conclusion:1. Long-lived embryo pills add the taste side and the fetus protection work leak, for the clinical treatment spleen kidney two empty embryos painful fetal movement, the abortion effect affirmation effective side medicine, in particular adds the taste side addition and subtraction curative effect in the improvement clinical symptom aspect long-lived embryo pill to have to surpass the fetus protection spirit. 2. Miscarriage number of times are more, the pregnancy miscarries once more the possibility is bigger, the fetus protection treatment curative effect is smaller, this possible and miscarries many times damages the endometrium to have the connection, "cultivates it to damage is the fetus protection treatment key in advance".3. Blood HCG, the P examination may take the early gestation period judgment is pregnant the pouch, the embryo growth grows and judges one of prognosis referential targets, the long-lived embryo pill adds the taste side and the fetus protection works has improves Huang Tihuang the body function, promotion blood HCG, the P growth is helpful in the pregnancy continuation4. Long-lived embryo pill adds the taste side addition and subtraction and the fetus protection works may reduce the?-endorphin which elevates because of the stress from the god internal secretion and the immunity factor adjustment aspect to the pregnancy maintenance has certain function.But the long-lived embryo pill adds the taste side the peptide aspect to be more prominent in depression in, infers the Chinese medicine use "rather the heart to calm the nerves" initially to reduce organism the stress to cause?-endorphin secretion to reduce is helpful to the pregnancy continuation.5. Long-lived embryo pills add the taste side and the fetus protection work possibly reduce or the elimination existence blood serum are helpful from the build immune body or the homogeneous foreign body immune body to the pregnancy, but the long-lived embryo pill adds the taste side to add and subtract possibly has the curative effect, also the Chinese medicine treatment compares the western medicine security, does not have the side effect.Is worth further studying.6. Has the miscarriage or has when the miscarriage symptom the circumference blood NK cell activeness to strengthen the Th1 cell factor the secretion increase, the long-lived embryo pill adds the taste side and the fetus protection works possibly reduces the circumference blood NK cell activeness and reduces the Thl cell factor the secretion, promotes the Th2 cell factor secretion, adjusts the Th1/Th2 cell factor the balance to the Th2 direction displacement, reduces it is helpful to the embryo cell toxicity and the immunity damage function to the pregnancy continuation, but the long-lived embryo pill adds taste Fang Suizheng to add and subtract in this aspect possibly must surpass the fetus protection spirit.7. Invigorates the kidney the profit to be mad the peaceful embryo Chinese native medicine medication security, to the parent substance non-toxic side effect, an antithetical couplet generation of birth and the growth growth has not affected.But still had further the long time revisit observation and the filial generation intelligence growth situation observation, also needed to carry on aspect and so on reproduction toxicity, heredity toxicity to it further research. 8. Progresses through the review and the summary Chinese medicine all previous dynasties literature and the modern medical research, the motherland medicine thought the kidney empty damages, the vitality insufficient, flushes no matter what damages, the embryo Yuan does not solidify is the main pathogenesis, but the kidney not solid embryo, the spleen loses conserves health causes the embryo Yuan not to solidify is the morbidity key, but the modern medicine miscarries the multi-consideration internal secretion immunity factor about recurrence routine. |
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