Study On The Preparation And The Quality Standards In Jianweiqutong Pellets

Objective:Jianweiqutong Pellets freckle-Preparation of research and quality standards for the treatment of stomach trouble of the new film-coating formulations and provide agents on the basis of quality control.Methods:prescription analysis and retrieval line screening to determine the extraction process routes to hydrochloride berberine, Chlorogenic Acid leaching capacity of the indicators of the impact of leaching factors were selected through single factor compared to Chlorogenic Acid retention rate as an index Optimization Alcohol Shen process conditions; By comparing the experimental study of alcohol extract separate drying and mixing different temperatures and dry conditions under vacuum drying on the hydrochloride berberine by HPLC impact of the collapse of indicators, the combination of granulation process and compression parameters gifted freckle-election Jianweiqutong Pellets best molding process conditions; done by TLC Identification; using High Performance Liquid Chromatography (HPLC) determination, and methods of inspection.Results:Chinese goldthreadand so on ethanol extraction, dandelion and so on water mention. Ethanolic extract optimum conditions:80% ethanol immersion 1.5 hours, heating to extract two times, and alcohol respectively 8,6 times, the extraction time is 2.5,2.0 hours. Water extract optimum conditions:1.5 hours soaking water, extracting two times, and the water was 8,6 times the medicine, the extraction time of 2.0 hours,1.5 hours,1.5 hours. Mention condensed water from liquid to a relative density of 1.15, by adding 95% ethanol, the volume of liquid containing alcohol was 60%, standing 24 hours after filtration, and alcohol extracts mixed vacuum drying between 60℃and 70℃Process conditions:drug powders:microcrystalline cellulose 46.5:53.5 10% ethanol solution,which is 30mL, Rotationl Speed of squeeze is 72r/min, Rotationl Speed of rolling is 1400 r/min, which costs 15 minutes. Chinese goldthreadand, Corydalis yanhusuo W.T.Wang TLC no negative interference, hydrochloride berberine Determination feasible, good repeatability.Conclusion:Preparation of viable, reliable quality standards and can be used for industrial production.