Separate And Reclaim Ribavirin From Crystal Effluent By Resin Column Chromatography-Crystal Progress

In this paper, groping experiments are processed to separate and reclaim the system of ribavirin crystal effluent. For the physical character of ribavirin and acetamide as main components, the preferable method of UV with equal adsorption at two different wavelengths is established. By the method, the solution can be detected accurately without interfere. Through experiments, the optimum conditions of resin column chromatography-crystal process are put forward to separate and purify the effluent. The technology is simple, feasible and nontoxic with no other accretion.Through static and dynamic experiments of resin adsorption, the preferable technical conditions of reclaiming ribavirin by LSD-311 resin are ascertained. LSD-311 resin has preferable adsorption and desorption performances, it can be used circularly, so it can be the medium of adsorption and chromatography. The adsorption model for ribavirin mass transfer with LSD-311 resin is also set up, the height of mass transfer zone and total mass transfer coefficient in different operation conditions are calculated, which can provide important reference to the design of adsorber.On the base of the resin adsorption experiments, the optimum technology of resin column chromatography-crystal process is established. The desorption condition of chromatography is studied, the resolution and the theoretical stage number are calculated. The ternary phase diagrams of ribavirin-acetamide-85% ethanol is determined to direct the crystal experiments. By the technology, ribavirin and acetamide can be separatedand purified from ribavirin crystal effluent at the same time.Li Hongli (Chemical Biology) Directed by Professor Zhang Xiaolin...