The Electrochemical Study On Neurotransmitter Dopamine And Small Molecular Drugs

Morden analytical chemistry has been developed as a new information science. Life phenomenon is often characterized by electrochemical phenomenon. Studying biomolecules with the electrochemical method can offer some scientific basis and useful information for the physiology of animals and plants. Therefore, it is one of the trends of chemistry to use electrochemical methods in studying biological phenomena. Dopamine (DA), the most significant catecholamine, belongs to the family of inhibitory neurotransmitters and plays a very important role in the functioning of central nervous, renal, hormonal and cardiovascular system. Extreme abnormalities of DA concentration levels may lead to several diseases such as pakinsonism. similarly. Ascorbic acid (vitamin C, AA) is used clinically in the treatment and prevention of scurvy. Ascorbic acid/ascorbate is a vital component in the diet of humans. Ascorbate is known to take part in several biologicalreactions and is present in mammalian brain. L-cysteine (L-Cys) could prohibit Vc molecule change and color appearance, and it could enhance disease-resistance in biological body. Thus study for neurotransmitter dopamine and small molecular drugs is a problem of critical importance in the field of neurochemistry and biomedical chemistry. In this paper, we have done some work on analysing L-Cys,DA and AA by electrochemical method. The main results are expressed as follows: 1. Expounded the challenges of life sciences to analytical chemistry and electroanalysis chemistry, and summarized the state of analysing dopamine and ascorbic acid by electrochemical method. 2. The preparetion of activated rough glass carbon electrode (ARE) in KMnO4 solution and its electrocatalytic oxidation for Ascorbic acid (AA) were studied. The resuits indicated that ARE showed higher electrochemical activity of ascorbic acid, and its mechanism of catalysis was studied.