Synthesis Of Mentalloporphrin-5-Fluorouracil Compounds With Different Mental Center

5-fluorouracil is a kind of anti-metabolic medicine wide used in clinic, which can block the metabolic link, impedes the synthesis of DNA, and then prohibits the propagation of the cancer cells. As a kind of anti-tumor, 5-fluorouracil have inhibition effects on many kinds of cancer, such as cervical cancer advanced colorectal cancer, nonresectable liver metastatic tumor, but it also seriously hurts the common cells and have severe complications at the same time~[1-2].In order to improve the target activity of anticancer medicine and reduce their untoward effects, the effective drug is expected with high selectivity.Porphyrins is a general term of the homologue and derivative of porphine with substitutinggroups at the outside ring, becoming mentalloporphyrms promptly after two protons on its nitrogen are replaced by the mental ion. Porphyrins and mentalloporphyrins exist in the animals and plants extensively and have special physiological activation.Porphyrin and metalloporphyrins have special affinity with cancer cell because their distinctive structure. They can be taken up and retained by tumor tissue selectively. With the appropriate light, they can produce fluorescence and kill the cancer cell.So the research on the use of porphyrin and metalloporphyrins for tumor localization and therapy has caused great interests of chemists, medicals and biologists.Aim to improve the target activity of anticancer medicines and decrease the toxicity, three porphyrin-5-Fluorouracil compounds and eight mentalloporphrin-5-Fluorouracil compounds were synthesized. The results are as follows:In the first part, three kinds of porphyrins and 5-Fluorouracil were linked up by carbonyl bonds. And eight novel metalloporphyrin-5-Fluorouracil compounds with different mental center (Mn, Zn, Cu) have been obtained. The structures of compounds have been characterized by UV, IR, ~1HNMR, MS and elemental analysis.In the second part, optimum reaction and separation conditions have been researched and improved. There are further works such as vitro anti-tumor activities test of the fourteen compounds still to be done.