Chlorophenyl Porphyrin 5 - Fluorouracil And Its Zinc Complex Synthesis

Porphyrin and metalloporphyrins have special affinity with cancer cell because of its distinctive structure. They can be taken up and retained by tumor tissue selectively. So the research on the use of porphyrin and metalloporphyrins for tumor localization and therapy have caused great interests of chemists medicals and biologists.In order to improve the target activity of anticancer medicine and reduce their untoward effects,the effective drug is expected with high selectivity,which means it can distinguish target cell from normal cell properly. Porphyrin and metalloporphyrins have special affinity with cancer cell because their distinctive structure.They can be taken up and retained by tumor tissue selectively.With the appropriate light,they can produce fluorescence and kill the cancer cell.5-Fluorouracil is a kind of popular antimetabolic drug used in clinic.It has the similar structure with uracil which is necessary to the cancer cell.It contents with uracil in the same enzyme system,blocks the metabolic link,impeds the synthesis of DNA,and then prohibits the propagation of the cancer cells.As a kind of antitumor drug,5-Fluorouracil has inhibition effect on many kinds of cancer.but it also seriously hurts the normal cells while it kills the cancer cells.In order to decrease the toxicity of 5-Fluorouracil,we synthesized a series of porphyrin-5-Fluorouracil and metalloporphyrin-5-Fluorouracil compounds. We expected these compounds can reach tumor tissue directly and kill cancer cell,so as to improve the curative effect.Furthermore, they cure cancer coordinating laser technology at the position of the body which the laser can reach for better curative effect.In this paper,we synthesized and charactered twelve porphyrin-5-Fluorouracil compounds and twelve novel zinc-5-Fluorouracil compounds. The results are as follows:In the first part,We synthesis twelve phenylporphyrin substituted by chloride at different position and then link 5-Fluorouracil by hydrocarbon chain in different length.The structures of twelve porphyrin-5-Fluorouracil compounds have been characterized by UV, IR, 'HNMR and MS. Porphyrin-5-Fluorouracil compounds occurred complexation reaction with zinc and twelve novel zinc-5-Fluorouracil compounds have been obtained.Their structures have been determined by UV and IR.In the second part .optimum reaction and separaion conditions have been reaserched and improved.