The Studies On The Purification Technology And Quality Standard Of The Carthamus Tinctorius Extraction

Objective: 1) In order to provide evidential support and methodology for Carthamus tinctorius extraction quality control process, we used the HPLC method to determine the content of hydroxysafflor yellow A in the Carthamus tinctorius extraction; 2) To evaluate the effectiveness of four kind of miscellaneous object ablation technologies on Carthamus tinctorius extraction, in order to select out economical, manufacture suitable ablation thechnology; 3)Quality control criteria for Carthamus tinctorius extraction., provide evidential support for it is quality differentiation. Methods: 1) We used the HPLC method to determine the content of hydroxysafflor yellow A in the Carthamus tinctorius extraction; 2) Study design monofactor designation and orthogonal designation, A comparative study was performed among four kinds of ablation technologies; 3) Preliminary investigation was held on the physiochemical characteristics of Carthamus tinctorius extraction, to establish quality control criteria, on this basis. Results: 1) The method of macroporous resin: the content of hydroxysafflor yellow A was66.12% and received residue was3.38%; 2) The method of ZTC- II clarifler: the content of hydroxysafflor yellow A was8.31% and received residue was28.12%. 3) The method of Ke ju tang: the content of hydroxysafflor yellow A was8.20% and received residue was28.04%; 4) The dre agravity was not surpass 10%, the total ash was not surpass 9%, the acid-insoluble ash was not surpass 3%. Conclutions: 1) It showed the method of HPLC was developed to determinate the content of hydroxysafflower yellow A in the Carthamus tinctorius extraction was stable and feasible. 2) The verification test make clear that the ablation thecnology was cheap, manufacture suitable and the universal evaluation method was representative; 3) the established quality control criteria can be effectively control the quality of Carthamus tinctorius extraction.