Study On The Preparation And Quality Standards Of Ziguiminkang Tablets

Ziguiminkang tablet is composed of twelve Chinese medicinal herbs, which is an effective prescription to cure allergic purpura. It has the functions of cooling blood and arresting bleeding, activating blood circulation and dissipating blood stasis, and reinforcing qi and consolidating the exterior.Most of the active substances in the prescription and theri pharmacologic action have been identified on the whole.Based on the former study results, the experiment extracted active substances according to their physical and chemical properties.The potential influence factors to the performance of extraction were fully considered.The techniques of water extract was designed in scientific and reasonable way with orthogonal design.The reasonable extract equipments and technique conditions were optimized by taking those representative effective constituents as citerion.Also, the process conditions of grinding , dying and formulation were studied before the processing parameters were determined.In order to guarantee the quality and curative effects of Ziguiminkang tablet, quality standard its set up was with the help of modern science and technology, such as microscope identification, TLC and HPLC. After a series of experimental studies, the most important traditional Chinese medicine herb in the prescription was controled quantitatively, and the quality standards were established.In addition, primary stability was tested in three lots of pilot study samples during the period of six months, and all the items covered the certification.The experimental result suggested that the technology of Ziguiminkang tablet convenient and feasible, the physical and chemical properties stable and the quality controllable.