Gu Jin Capsule Preparation Craft And Quality Specification Research

This article has conducted the research to the GuJin capsule preparation craft and the quality specification. The preparation craft research mainly through the orthogonal experiment,optimal best mellowly raises with the water fries withdraws the craft,through the formability experimental study, and smoothly transitsexperimental, thus provides the reasonable technical parameter for thebig production, the stability trial proved, this craft is feasible. The quality specification research mainly inspected the distinction, the inspection and the content determination project. The distinctionresearch mainly through the exclusive stronger thin HPLC to the Gu Jin Wan capsule in Radix et rhizoma notoginseng, Sanguis draconis, Semen strychni, Radix gentianae macrophyllae , Rhizoma corydalis, taste of a medicine and so on fumitory has conducted the research. The content determination has used the gentleman which in convenience quick highly effective liquid phase chromatography (HPLC) opposite party the host medicine Semen strychni contains strychnine with brucine, Radix gentianae macrophyllae contains Dentiopicrin has conducted thecontent determination research. This each grain contains brucine by the strychnine(C21H22N2O2) the idea, should be 0.30mg ~ 0.50mg; By the brucine(C23H26N2O4) the idea, does not have to be short to 0.20mg; Contains Radix gentianae macrophyllae by Dentiopicrin (C16H20O9) the idea, does not have to be short to 3.0mg. This quality specification can eliminate in the Chinese native medicine preparation the complex component disturbance, accurately to the prescription in DinsenosideRg1, Rb1, SanchinosideR1, Strychnine, Dentiopicrin, Tetrahydropalmatine and the Sanguis draconis uses up carries on the thin layer chromatograph distinction; To the strychnine, the brucine,Dinsenoside carries on the content determination, this method operation simple, reappears the nature and the accuracy is good. This research results, had guaranteed the GuJin capsule clinical uses the medicine the rationality, the security and the validity.