Research On Preparation And Antibronchitis Pharmacology For Eucalyptus Oil

Eucalyptus oil has functions of antibiosis, antioxygen and improving respiration. To take advantage of pharmacological effect and diminish its adverse gastrointestinal reaction, this thesis illustrates preparation process, physicochemical property and antibronchitis effect of Eucalyptus oil Beta-cyclodextrin inclusion compound.Orthogonal experiment design is used for funneling of process parameters. Optimized preparation parameters are identified as following ratio: Beta-cyclodextrin :Eucalyptus oil is 8:1, Beta-cyclodextrin: water is 1:10, inclusion time is 1 hour, inclusion temperature is 40℃. Research of physicochemical property of inclusion compound demonstrates that inclusion compound is stable and can be used for pharmaceutical development.Toxicity test of eucalyptus oil beta-cyclodextrin inclusion compound display it has minor toxicity on rats. Research on antibrochitis effect of inclusion compound use chronic bronchitis rat model that is produced by injecting LPS into trachea. Experiment result demonstrates inclusion compound can alleviate inflammation and pathological changes on rats.The result of the orthogonal experiment design for Eucalycalyptus oil Beta-cyclodextrin inclusion compound can be used for further medicinal product development. Besides, therapeutic effect of eucalyptus oil beta-cyclodextrin inclusion compound on rat model of chronic bronchitis is confirmed as a research conclusion.